急性心肌梗塞患者红细胞膜结合硒测定及临床意义  

The Determination of RBC Membrane Binding Selenium in AMI Patients and its Clinical Significance

作　　者：杨根元[1] 徐德选[1] 邢光伟[1] 陆德澄[2] 苏子杰[2] 凌玲[2] 

机构地区：[1]镇江医学院,212001 [2]镇江医学院附属医院

出　　处：《天津医药》1993年第7期407-409,共3页Tianjin Medical Journal

摘　　要：用氢化物-原子荧光法测定红细胞膜结合硒含量,测定健康者35人,膜结合硒均值为12.47±3.45μg/g 膜蛋白;AMI32例,膜结合硒均值为7.74±1.29μg/g 膜蛋白;心绞痛32例,膜结合硒均值为9.32±1.82μg/g 膜蛋白。结果表明,AMI 组和心绞痛组膜结合硒含量明显低于对照,差别高度显著(P<0.01)。AMI 组膜硒明显低于心绞痛组(P<0.01),提示膜硒与冠心病病变程度密切相关,病情越重膜硒降低越多。因此,膜硒可能是诱发冠心病特别是 AMI 的危险因子。所以,膜结合硒有可能作为预防、诊断和治疗 AMI 的一个指标。该方法的回收率为96.23%～100.70%,相对标准偏差<4.80%。The present studay was performed to determine the amount of RBC membranebinding selenium in heart diseases by hydride generation-atomic fluorescence spectro-metry.In 35 healthy subjects,the mean selenium was 12.47±3.45 μg/g membrane pro-tein;in 32 AMI and 32 angina pectoris patients the values were 7.74±1.29 and 9.32±1.82μg/g respectively.The results revealed that membrane Se in those heart diseaseswas significantly lower than that in control group(P<0.01).Furthermore,membraneselenium in AMI group was significantly lower than that in angina pectoris group(P<0.01).The results suggested that the amount of membrane Se was correlated to the con-dition of coronary heart diseases.The more severe the disease,the lower the mem-brane Se.Therefore,decrease of membrane Se may be a factor inducing coronary he-art disease especially AMI and may be regarded as an index relating to the prevent-ion,diagnosis and treatment of AMI.

关 键 词：急性 心肌梗塞 原子荧光光谱 硒 

分 类 号：R542.22[医药卫生—心血管疾病]