西苯唑啉及常咯啉合用的抗实验性心律失常作用  

The Effects of Cibenzoline and Changrolin and Their Combination on Experimental Arrhythmias

作　　者：李梅[1] 张京玲[1] 张才丽[1] 

机构地区：[1]天津医学院药理教研室,300070

出　　处：《天津医药》1993年第8期460-463,共4页Tianjin Medical Journal

摘　　要：利用乌头碱诱发大鼠实验性心律失常模型研究西苯唑啉、常咯啉及两药合用的抗心律失常作用。静脉注射不同剂量的西苯唑啉、常咯啉均可推迟大鼠心律失常的发生,与对照组有显著差异。西苯唑啉1mg/kg 加常咯啉0.7mg/kg 可显著增强其抗室扑、室颤作用。0.5mg/kg 西苯唑啉及0.7mg/kg 常咯啉单用,室早、室颤的相应乌头碱公斤体重累积量与对照组比无显著差异,合用后有显著差肄。斜率比五点法的研究表明两药合用的抗室早、室颤作用有提高。西苯唑啉、常咯啉有较好的抗乌头碱心律失常作用,两药小剂量合用抗心律失常作用协同。The effects of cibenzoline,changrolin and combination of two drugs on aconitineinduced arrhythmias in rats were studied.Different doses of cibenzoline or changro-lin iv.could delay the onset time of arrhythmias,respectively,and the results hadsignificant difference comparing with the control group.The combination of 1mg/kgcibenzoline and 0.7mg/kg changrolin iv,presented potentiated effects in anti-ventri-cular flutter and fibrillation.Compared with the control group,cibenzoline 0.5mg/kgor changrolin 0.7mg/kg iv.singly had no significant difference on the doses of acon-itine to induce the ventricular premature systole and fibrillation,but when those twodrugs were used together,there were significant difference.The study using ratio ofslope five-point biological assay also comfirmed that the two drugs combination couldincrease the anti-arrhythmic effects.As shown in the experiment,the anti-arrhythmiceffects of two drugs and single drug were all significant compared with that of cont-rol group and indicated by many ways that small dose combination group presentedsynergism.

关 键 词：西苯唑啉 常咯啉 抗心律失常药 

分 类 号：R972.2[医药卫生—药品]