完全疏水化酰化壳聚糖的制备及反应条件的研究  

Preparation of Fully Hydrophobic Acylated Chitosan and Effect of Reaction Conditions

作　　者：刘超[1] 辛梅华[1] 李明春[1] 汪敏[1] 冯震[1] 

机构地区：[1]华侨大学材料科学与工程学院,福建泉州362011

出　　处：《中国医药工业杂志》2005年第2期76-78,共3页Chinese Journal of Pharmaceuticals

摘　　要：制备了完全疏水化的脂肪长链酰化壳聚糖,并用元素分析、红外光谱和核磁共振进行表征。研究了反应条件对酰化度的影响,结果表明:在吡啶-氯仿(2∶1)介质中,分子量最低的壳聚糖酰化度最高。通过对完全酰化产物进行选择性还原,可获得两亲性N,N-双酰化壳聚糖。Fully hydrophobic acylated chitosan was prepared and characterized by elemental analysis, FTIR and 1HNMR. The effects of reaction conditions on the average acylation degree of chitosan were investigated. The results showed that in the pyridine-chloroform (2∶1) medium, the highest acylation degree could be obtained using the lowest molecular chitosan. The amphiphilic N,N-diacylated chitosan could be gained by selective reduction of fully acylated chitosan.

关 键 词：壳聚糖 酰化 疏水化 选择性还原 

分 类 号：O636[理学—高分子化学]