Inhibition of Albendazole and Oxfendazole on the Activity of Fumaric Reductase in Cysticercus cellulosae  

作　　者：GAOXue-jun LIQing-zhang LIXia 

机构地区：[1]AnimalMedicineCollege,NortheastAgriculturalUniversity,HarbinHeilongjiang150030,PRC

出　　处：《Journal of Northeast Agricultural University(English Edition)》2004年第2期156-159,共4页东北农业大学学报（英文版）

基　　金：SupportedbytheNationalNaturalScienceFoundation(30371081)

摘　　要：The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected. Results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase. The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death.The activity of fumaric reductase in Cysticercus cellulosae tissue homogenate with albendazole and oxfendazole individually was detected. Results showed that the two kinds of drugs both could inhabite the activity of fumaric reductase. The results indicate that the mechanism of action of benzimidazole carbamate drugs is probably inhabiting the complex of fumaric reductase noncompetently, thus lead to the exhaostion of energy and death.

关 键 词：ALBENDAZOLE OXFENDAZOLE Cysticercus cellulosae fumaric reductase 

分 类 号：S859.795[农业科学—临床兽医学]