头风饮改善实验性大鼠微循环障碍的研究  

Study on the effect of Toufeng Yin on improving microcirculation in rats

作　　者：王雅[1] 包旭[1] 张建萍[2] 王正荣[2] 包定元[2] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学华西基础医学与法医学院,四川成都610041

出　　处：《华西药学杂志》2005年第1期23-26,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的观察头风饮对实验性大鼠肠系膜微循环障碍的改善作用。方法大鼠ip戊巴比妥钠 5 0mg·kg-1麻醉 ,十二指肠内给予头风饮 (生药 3. 0、6 .0、12 .0g·kg-1) ,2 0min后 ,在肠袢肠系膜观测区滴加 1∶1× 10.5盐酸肾上腺素 10 μl,滴加前、后的不同时间用微循环显微镜观察肠系膜微血管管径、血液流态及毛细血管网交点计数的变化情况 ,观察记录直至肠系膜观测区微循环恢复至滴加盐酸肾上腺素前的情况为止。结果生药 6 .0、12 .0g·kg-1能非常显著地缩短盐酸肾上腺素所致肠系膜血管血流减慢或停滞的恢复时间 ;具有显著地拮抗盐酸肾上腺素收缩肠系膜微动脉、静脉血管的作用 ;相同剂量可显著改善盐酸肾上腺素所致肠系膜微动脉、静脉血液血流减慢或停滞的作用 ,并且显著地增加肠系膜毛细血管网交点的开放数。结论头风饮在大鼠十二指肠内给药具有显著地改善肠系膜微循环的作用。OBJECTIVE To observe the effect of Toufeng Yin(TFY) on improving experimental mesenteric microcirculation in rats. METEODS The rat was anesthetizied by ip Pentobarbital sodium (50 mg·kg -1), and then fixed upwards. After cutting the right side of celiac wall,the end of jejunum was drawed out and tied on the affusion pool. Then TFY was administered to duodenum through injection at the dose of 3.0,6.0,12.0 g·kg -1,respectively. After 20 minutes, 10 μl of Adrenaline hydrochloride(1∶1×10 5) was added to the mesenteric observing-section at the end of jejunum. The diameter changes, the mesenteric micro-vessels, the blood flowing state and the junction amount of capillary network were observed and recorded. Till the mesenteric microcirculation resumed to the state before the adding of Adrenaline hydrochloride. RESULTS TFY at the dose of 6.0 and 12.0 g·kg -1 could remarkably shorten the resuming time of the mesenteric blood flowing state caused by Adrenaline hydrochloride.So TFY could apparently antagonize the effect of Adrenaline hydrochloride, which could shrink the mesenteric micro arteries and veins. TFY at the same dosage could dramatically ameliorate blood circulation of the mesenteric micro arteries and veins, and it could observably increase the opening points of the junction of capillary network on the mesentery. CONCLUSIONThe administration of TFY to the duodenum can effectively improve the mesenteric micro circulation.

关 键 词：肠系膜微循环 头风 盐酸肾上腺素 实验性大鼠 生药 血流 微循环障碍 显微镜观察 毛细血管网 改善 

分 类 号：R285.5[医药卫生—中药学] R277[医药卫生—中医学]