高精度散射光度滴定法测定盐酸异丙嗪的含量  

Determination of Promethazine hydrochloride by Highly-accurate nephelometric titration

作　　者：张琦[1] 詹先成[1] 李成容[1] 李琳丽[1] 林涛[1] 何宁[1] 尹小东[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第1期34-35,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目 (批准号 :3 0 171117)

摘　　要：目的　探讨高精度散射光度滴定法测定盐酸异丙嗪含量的可行性。方法　用四苯硼钠标准溶液滴定盐酸异丙嗪溶液 ,采用 0 .5 %聚乙烯吡咯烷酮溶液作为胶体保护剂。将测定结果与非水滴定法、电位滴定法和非水电位滴定法比较。结果　高精度散射光度滴定法含量测定结果的精密度小于 0 .2 %。F检验结果表明该方法精密度与药典方法相当 ;t检验结果表明方法的均值与药典方法无显著性差异。结论　所用方法可以用于盐酸异丙嗪的含量测定。OBJECTIVE To investigate the applicability of Highly-accurate nephelometric titration in the determination of Promethazine hydrochloride. METHODS Promethazine hydrochloride formed PMH-TPB collosol quantitatively with sodium tetraphenylboron in an acidic medium. In the titration, the sodium tetraphenylboron solution was used as a titrant and 0.5% pholyvinylpyrrolidone solution was added as a colloid stabilizer. The contents of promethazine hydrochloride determined by Highly-accurate nephelometric titration were compared to those determined by Nonaqueous titrations, Potentiometric titration and Nonaqueous potentiometric titration. RESULTS The precision of Highly-accurate nephelometric titration was better than 0.2% under suitable experiment conditions, which was comparable to that of the Pharmacopoeia methods by F-test. The accuracy of Highly-accurate nephelometric titration was comparable to that of the Pharmacopoeia methods by t-test. CONCLUSION The Highly-accurate nephelometric titration could be applied in the content determination of Promethazine hydrochloride.

关 键 词：盐酸异丙嗪 高精度散射光度滴定法 药典 含量测定 测定结果 T检验 四苯硼钠 均值 液滴 精密度 

分 类 号：R927[医药卫生—药学] R917