邻苯三酚法测定超氧化物歧化酶缓释片中SOD的活性  

Determination of superoxide dismutase activity in its sustained release tablets by Pyrograllol autoxidation

作　　者：蔡骏[1] 李颖[1] 尹宗宁[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第1期54-55,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的建立超氧化物歧化酶 (SOD)缓释片的活性测定方法。方法采用邻苯三酚自氧化法。结果在SOD浓度为 0 .0 6 0～0 . 0 0 6mg·ml-1时线性关系良好 (r=0 .9996 ) ;平均空白加样回收率为 10 1 .94 % (n=9)。结论所用方法简单、快速 ,结果准确。OBJECTIVETo establish a method for determination of superoxide dismutase activity in its sustained release tablets. METHODSThe method of Pyrograllol autoxidation was used. RESULTSThe linearity was good within the range of 0.060-0.006 mg·ml -1(r=0.9996).The average recovery was 101.94%(n=9).CONCLUSIONThe proposed method appears to be simple, rapid, accurate and reliable.

关 键 词：缓释片 超氧化物歧化酶(SOD) 超氧化物歧化酶 邻苯三酚自氧化法 活性测定 方法 线性关系 

分 类 号：R446.11[医药卫生—诊断学] Q503[医药卫生—临床医学]