肺癌组织中α_1-抗胰蛋白酶的表达及生物学特征  

The expression and biological characteristics of alpha1-antitrypsin in lung cancer tissues.

作　　者：韩勇[1] 徐晖[1] 朱江 王云杰[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安7100382 [2]陕西省肿瘤医院胸外科,陕西西安710061

出　　处：《现代肿瘤医学》2005年第1期16-19,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助(项目编号: 30271461)

摘　　要：目的　研究α1AT(α1 -antitrypsin)在肺癌组织中的表达及其病理学意义。方法　检测 141例肺癌患者及 162例正常对照血清α1AT活性。通过免疫组化方法研究α1AT在肺癌组织中的表达,分析其与肺癌组织分型、分化程度及临床分期的关系。结果　α1AT活性在肺癌患者中明显降低,α1AT活性低者肺癌发生的危险性升高。肺癌组织α1AT表达显著升高,α1AT表达与肺癌的临床分期相关,但与肺癌组织类型无关。结论　α1AT在肺癌的发展与演进中可能具有重要的意义。objective To discuss the expression of α 1 AT in lung cancer tissues and its biological characteristics. Methods The activities of α 1AT in serums from 141 lung cancer patients and 162 normal people were assayed. Immunohistochemical study on the expression of α 1AT in lung cancer tissues was observed, and the correlation between the expression of α 1AT in the lung cancer tissues and different cell types, differentiation, as well as clinical stages of lung cancer were studied. Results The activity of α 1AT in serum from lung cancer patients was significantly decreased. The risk of lung cancer was increased in people with low α 1AT activity. The expression of α 1AT was markedly increased in tumor tissues, and was also significantly related to the lung cancer clinical staging, but it was not related to the cell types of lung cancer. Conclusion α 1AT might be related to the biological behavior of lung cancer.

关 键 词：肺癌 Α1-抗胰蛋白酶 

分 类 号：R734.2[医药卫生—肿瘤]