三种泻心汤及其类方不同配伍对正常大鼠胃粘液成分的影响  

Effect of 3 kinds of Banxiaxiexin Decoction and its dismantlements on the amount of gastric mucus in rats

作　　者：高艳青[1] 司银楚[1] 尚景盛[1] 文仁都[1] 牛欣[1] 

机构地区：[1]北京中医药大学,北京100029

出　　处：《中成药》2005年第1期69-74,共6页Chinese Traditional Patent Medicine

基　　金：211工程重点资助项目课题(2000004)

摘　　要：目的探讨半夏泻心汤及其类方不同配伍对正常大鼠粘液含量的影响。方法用均匀设计法对半夏泻心汤及其类方进行组方药量变化,以胃粘液含量为药理学指标,对所得的药理实验数据进行逐步回归分析。结果与胃粘液含量关联度最大的为黄连,可以显著降低其含量,其次对半夏、大枣和甘草的交互项,可增加胃粘液含量。药物之间存在复杂的交互作用。结论均匀设计为研究类方配伍提供了一种可供参考的试验设计方法。AIM:To investigate the influence of pinellia heart-draining Decoction, Licorice heart-draining Decoction, Fresh ginger heart-draining Decoction and its dismantlements on the amount of gastric mucus in rats. METHODS:20 different combination of Banxiaxiexin Decoction and its analogus according to the unform design layout, the amount of gastric mucus in rats was determinated. Stepwise regression analysis was adopted to estimate the relationship between the pharmacological data and compatibility. RESULTS:Rhizoma Coptidis could reduce the amount of gastric mucus remarkbably, the interaction of Rhizoma Pinelliae、Fructus Ziziphi Jujubae and Radix Glycyrrhizae could increase the amount of gastric mucus, and interaction was confirmed among different medicinal ingredients in prescription. CONCLUSION:Uniform design provides a referable exeperimental design for studying analogus decoction compatibility law.

关 键 词：半夏泻心汤 类方 胃粘液 均匀试验设计 

分 类 号：R285.6[医药卫生—中药学]