超声乳化溶剂扩散法制备阿奇霉素超细粉体  

Preparation of Azithromycin Microparticles by Ultrasonic Emulsification Solvent Diffusion Method

作　　者：龙涛[1] 田熙科[1] 杨超[1] 罗东岳[1] 费进波[1] 皮振邦[1] 

机构地区：[1]中国地质大学材料科学与化学工程学院,湖北武汉430074

出　　处：《武汉大学学报（理学版）》2004年第6期665-668,共4页Journal of Wuhan University:Natural Science Edition

基　　金：武汉市科技公关项目(20046001050);中国地质大学优秀青年教师基金资助项目(CUGQNL030)

摘　　要：采用超声乳化溶剂扩散法制备了阿奇霉素超细粉体,讨论了溶剂、温度、阿奇霉素浓度以及稳定剂种类和用量等条件对微粉粒径及形貌的影响.实验结果表明,在实验选定的最佳实验条件下(结晶温度0～5℃,阿奇霉素浓度0.03mol/L,1%聚乙二醇(PEG)、乙醇为溶剂),可制备出平均粒径为500nm的均匀分散阿奇霉素超细粉体.Ultrafine particles of a poorly water-soluble drug, Azithromycin, were produced by a new method, ultrasonic emulsification sovent diffusion. The produce was characterized by SEM and FT-IR. The effect of solvent, time, temperature and stabilizer on the produce's morphology was studied. The results show that the optimal condition is: crystal temperature 0-5 ℃, duration of action 2 h, stabilizer 1% PEG, concentration of Azithromycin 0.03 mol/L. Under the optimal condition the partice average size of Azithromycin reaches 500 nm.

关 键 词：阿奇霉素 溶剂扩散 超细粉体 超声乳化 

分 类 号：O644.3[理学—物理化学]