哌嗪雌酚酮对老年大鼠腰椎骨代谢的影响  

The effects of new compound of piperazinyl estrone on lumber veterbra in aged rats

作　　者：武晓蓉[1] 李青南[2] 翁玲玲[3] 郑虎[3] 

机构地区：[1]广东药学院药理教研室,广东广州510240 [2]广东医学院骨生物学研究室,广东湛江524023 [3]四川大学华西药学院药物合成室,四川成都610041

出　　处：《广东药学院学报》2004年第6期647-649,653,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金资助项目 (No .394 30 12 0 )

摘　　要：目的研究新合成化合物哌嗪雌酚酮对雌性老年大鼠腰椎骨代谢及子宫的影响。方法 32只 2 2月龄SD大鼠 ,随机分为 4组 :对照组 (生理盐水 0 .1mL/kg·d-1) ,哌嗪雌酚酮高、中、低剂量组 (2、1和 0 .5mg/kg·d-1) ,皮下注射 30d ,取第 5腰椎行不脱钙骨制片骨形态计量学测量分析 ,同时取子宫称重。结果与对照组比较 ,哌嗪雌酚酮组骨量增加。其中中剂量 (1mg)组骨形成增加 ,骨吸收降低 ,骨量增加差异有显著性 ;子宫重量无明显变化。结论哌嗪雌酚酮可有效预防老年大鼠骨质减少 ,中剂量 (1mg)组效果最明显 。Objective To study the effects of piperazinyl estrone(P-E), a new estrogen derivant, on bone turnover, bone mass and uterine weight in female aged rats. Methods Thirty-two Sprague-Dawley female rats at the age of 22 months were rando mLy divided into four groups. 8 rats in each: PE-treated (high,mid,low) group and control. After being injected subcutaneously for 30 days, all rats were sacrificed. Bone histomorphometric analysis of the lumbar vertebrae was performed in undecalcified sections and uterine weight were measured. Results Compared with controls, bone mass was increased in P-E groups. Data showed that bone resorption were decreased, bone formation was stimulated and bone mass was increased significantly in P-E (1 mg/kg day) group . The uterine weight has no significant change. Conclusion The findings of this study indicate that piperazinyl estrone at dosage of 1mg/kg/d has a notable effect on preventing the bone losses in aged rats and has no negative effect on uterus.

关 键 词：哌嗪雌酚酮 老年大鼠 骨质疏松 雌激素 子宫 

分 类 号：R96[医药卫生—药理学]