SARS病人临床及细胞免疫特征分析  

The Clinical and Cellular Immune Features of 35 Patients with Severe Acute Respiratory Syndrome (SARS)

作　　者：罗显荣[1] 程涛[1] 李灼亮[1] 伍伟玲[1] 刘树仁[1] 谢庆[1] 

机构地区：[1]解放军第458医院,广东广州510602

出　　处：《医学临床研究》2004年第9期1003-1006,共4页Journal of Clinical Research

摘　　要：【目的】探讨严重急性呼吸综合征(SARS)的临床和细胞免疫特征。【方法】回顾分析本院收治的 35例SARS病人的临床特征,并与普通肺炎病人进行比较。同时用流式细胞仪检测了13例SARS病人和10 例健康志愿者的外周血CD4+和CD8+T淋巴细胞。【结果】SARS病人最常见的表现为发热、咳嗽、头痛、全 身肌肉酸痛,淋巴细胞减少。13例SARS病人外周血CD4+和CD8+自发病第1周至第四周均明显降低,以发 病第2周最明显。胸部X线表现为进行性发展的多发性肺浸润病灶。【结论】SARS是一个严重的呼吸系疾 病,主要表现为发热、咳嗽、头痛、全身肌肉酸痛。检查有外周血淋巴细胞计数减少,CD4+和CD8+明显降低, 肺内多发性浸润病灶。ObjectiveTo explore the clinical and cellular immune features of severe acute respiratory syndrome (SARS).The clinical features of 35 patients with SARS admitted and treated in our hospital during past 5 months were analyzed retrospectively and compared with 35 patients with common pneumonia . Consecutive blood samples were collected from 13 patients with SARS and 10 healthy volunteers. The CD 4 + and CD 8 + counts in their T cells of peripheral blood were detected by flow cytometry.The most common symptoms seen in patients with SARS included fever (100% of the patients); cough (74.3 %), headache and myalgia (45.7 %), lymphopenia (57.1%). The numbers of CD 4 + and CD 8 + in peripheral blood of 13 patients with SARS significantly decreased from the first to fourth week since the onset of disease, especially prominent in the second week. Serial chest X-ray films showed progressive multi-foci of infiltration in the lungs.[Conclusion]SARS is a serious disease of respiratory system. Its main clinical manifestations are fever, cough, headache, and generalized myalgia. Examination of peripheral blood displays lymphopenia and obvious decrease in CD 4 + and CD 8 + counts. In addition, multi-foci of infiltration in the lungs are usually found by X-ray chest films.

关 键 词：肺炎 免疫 细胞 

分 类 号：R563.13[医药卫生—呼吸系统]