不孕症妇女宫颈黏液抗精子抗体与解脲支原体感染的关系  

The Relationship of Antisperm Antibodies in Uterine Cervix Mucous Fluid of Infertile Women to Ureaplasma Urealyticum Infection

作　　者：邓朝晖[1] 马赟[2] 唐慧珍[2] 贾政军[2] 

机构地区：[1]中南大学医学遗传学国家重点实验室 [2]湖南省妇幼保健院,湖南长沙410008

出　　处：《医学临床研究》2004年第11期1278-1279,共2页Journal of Clinical Research

摘　　要：【目的】探讨不孕症妇女宫颈黏液抗精子抗体 (AsAb)产生与生殖道解脲支原体 (UU )感染的关系。【方法】对 137例女性不孕患者宫颈黏液的AsAb采用酶联免疫法 (ELISA)进行检测 ,使用RocheLightCy cle荧光定量PCR检测仪对标本进行UU检测。【结果】137例不孕症患者中 ,发现抗精子抗体阳性组解脲支原体检出率为 6 9.4 % ( 5 0 / 72 ) ,抗精子抗体阴性组解脲支原体检出率为 32 .3% ( 2 1/ 6 5 ) ,两组之间差异有显著性 ( P <0 .0 5 )。对抗精子抗体、解脲支原体均为阳性组进行了两种治疗方法的疗效对比 ,结果表明 ,使用抗生素组抗体转阴率为 73% ,未使用抗生素组抗体转阴率为 37.5 % ,两组疗效差异有显著性 (P <0 .0 5 )。【结论】AsAb的产生与生殖道感染UU有密切的关系 ,后者可能是引起女性免疫性不孕的重要因素。积极治疗生殖道感染有助于降低AsAb滴度 ,阻止AsAb形成 。ObjectiveTo investigate the relationship between the production of antisperm antibodies(AsAb) in uterine cervix mucous fluid of infertile women and Ureaplasma Urealyticum(UU) infection of genital tract.The AsAbs in the uterine cervix mucous fluid of 137 infertile women were detected by enzyme linked immunosorbent assay(ELISA), and UU in these specimens was examined on the quantitative fluorescence PCR detector using Roche Light Cycle.Among 137 cases, the detection rates of UU in AsAb(+)group and AsAb(-)group were 69.4%(50/72)and 32.3%(21/65), respectively(P<0.05). Two types of therapy were undertaken in group showing AsAb (+) and UU infection (+), the negativity turning rates in women giving antibiotics and those without antibiotics were 73% and 37.5%, respectively (P<0.05).[Conclusion]AsAb production is closely related with the UU infection in genital tract, which may be the important factor causing women immunity infertility. Intensive treatment of genital tract infection is helpful to the decline of AsAb titer and inhibits the formation of AsAb, so it is beneficial to the treatment of women immunity infertility.

关 键 词：不良 女(雌)性/生物学 宫颈黏液 精子 自身抗体 尿素支原体感染 

分 类 号：R711.6[医药卫生—妇产科学]