ABO血型不合的异基因造血干细胞移植后红系恢复多因素分析  

Multiple Factors in Erythrocytic Recovery Following ABO incompatible Allogeneic HSCT

作　　者：黄晓军[1] 刘代红[1] 许兰平[1] 韩伟[1] 江倩[1] 陈育红[1] 张耀臣[1] 刘开彦[1] 鲍立[1] 陆道培[1] 

机构地区：[1]北京大学人民医院血液病研究所

出　　处：《中国实验血液学杂志》2004年第6期812-815,共4页Journal of Experimental Hematology

摘　　要：本研究目的是探讨ABO血型不合的异基因造血干细胞移植后影响红系恢复时间的多种因素。应用Cox回归模型对 15 7例ABO血型不合的allo HSCT患者的性别、年龄、移植方式、HLA相合 /HLA不合、预处理方案、GVHD预防、Ⅰ Ⅳ度GVHD发生、CMV感染及血型不合的类型进行多因素综合分析。结果表明 :经Cox回归多因素综合分析 ,次要血型不合、输注的有核细胞数、年龄和非血缘关系的骨髓移植 ,为影响红系恢复时间的 4个主要因素。结论 :次要血型不合及输注细胞数多的患者红系恢复较快 ,而年龄大和非血缘骨髓移植的患者红系恢复慢。This study was aimed to investigate various factors influening erythrocyte recovery following ABO incompatible allogeneic HSCT. 157 patients following ABO incompatible allogeneic HSCT were selected for the investigation. Cox regression analysis were used to identify the statistically significant factors including sex, age, schemes of transplantation, HLA matched, mismathed, conditioning regimens, preventive measures for GVHD, occurrence of grade Ⅰ-Ⅱ GVHD, CMV infections and types of incompatible blood group. The results showed that minor ABO incompatible, number of mononuclear cells infused, age of patients and unrelated BMT were four inportant main factors influening the erythrocyte recovery. In conclusion, the erythrocyte recovery is more quick in patients with minor ABO incompatible and more number of mononuclear cells infused, while it is slow in patents with old age and unrelated BMT.

关 键 词：ABO血型不合 异基因造血干细胞移植 红细胞 

分 类 号：R457.11[医药卫生—治疗学] R457.7[医药卫生—临床医学]