人造血干细胞的免疫缺陷小鼠移植模型研究与应用  

The Immuno Deficient Mice Transplantion Models in Study of Human Hematopoietic Stem Cells——Review

作　　者：胡东[1] 黄士昂[1] 

机构地区：[1]湖北省暨华中科技大学同济医学院附属协和医院干细胞中心,武汉430022

出　　处：《中国实验血液学杂志》2004年第6期875-879,共5页Journal of Experimental Hematology

基　　金：国家重点基础研究发展规划( 973)资助课题 ( 0 0CB5 10 10 3) ;国家杰出青年基金 ( 2 0 0 3)资助课题 ( 30 2 2 5 0 38)

摘　　要：已有多种免疫缺陷动物被用于人造血干 /祖细胞的检测。理想的免疫缺陷动物应具有完整的免疫缺陷 ,能高效的移植人造血干 /祖细胞 ,又有足够长的寿命能适于观察。通过介绍Nude、SCID、Nod/SCID、NOD/SCID β 2mnull等一系列免疫缺陷小鼠的遗传及免疫学特点及其在造血干细胞研究中的贡献。本文综述了小鼠移植模型的发展 ,评价了免疫缺陷移植模型在造血干细胞研究中的重要性及小鼠移植模型的新进展和方向。A variety of immuno deficient animal models has been used in the detection of human hematopoietic stem/progenitor cells and up to date make many remarkable contribution to the study of detectron cell biology. An ideal immuno deficient animal should not only have complete immune defects, be able to transplant human hematopoietic stem/progenitor cells with high efficacy, but also survive long enough for observation. In this review, the development of immuno deficient mice from nude, SCID, to NOD/SCID etc is introduced and much attention is put on the features, priority and shortcomings of those key animal models and their application in HSC research. The progress, the future directions and prospects of these immuno deficient mice models are stressed.

关 键 词：造血干/祖细胞 免疫缺陷小鼠 异种移植模型 

分 类 号：R332[医药卫生—人体生理学] R457.7[医药卫生—基础医学]