单核苷酸多态性及其在异基因造血干细胞移植中的应用  

Single Nucleotide Polymorphism and Its Application in Allogeneic Hematopoietic Stem Cell Transplantation——Review

作　　者：李素霞[1] 

机构地区：[1]中国人民解放军总医院血液科,北京100853

出　　处：《中国实验血液学杂志》2004年第6期885-888,共4页Journal of Experimental Hematology

摘　　要：单核苷酸多态性是继限制性片段长度多态性 ,短串连重复序列多态性之后的第三代遗传标记 ,是基因组中变异最多的一种 ,被广泛应用于基因定位、克隆和遗传多样性研究以及法医学亲子鉴定等方面。作为一种稳定的遗传多态性 ,单核苷酸多态性成为异基因造血干细胞移植中嵌合体检测的新方法。本文就单核苷酸多态性的遗传特性 ,分析技术 ,在造血干细胞移植和其它方面的应用进行了综述。Single nucleotide polymorphism (SNP) is the third genetic marker after restriction fragment length polymorphism (RFLP) and short tandem repeat. It represents the most density genetic variability in the human genome and has been widely used in gene location, cloning, and research of heredity variation, as well as parenthood identification in forensic medicine. As steady heredity polymorphism, single nucleotide polymorphism is becoming the focus of attention in monitoring chimerism and minimal residual disease in the patients after allogeneic hematopoietic stem cell transplantation. The article reviews SNP heredity characterization, analysis techniques and its applications in allogeneic stem cell transplantation and other fields.

关 键 词：单核苷酸多态性 遗传标记 异基因造血干细胞移植 异基因嵌合体 

分 类 号：Q74[生物学—分子生物学] R457.7[医药卫生—治疗学]