养寿丹对Alzheimer病模型大鼠细胞因子的影响  

Experiment study on inhibiting the excessive expression of cytokine in Alzheimer’s Disease rat after using Yang Shoudan(养寿丹)

作　　者：王玲[1] 黄兆胜[1] 刘明平[1] 熊平[1] 赵珍东[1] 罗倚珊[1] 

机构地区：[1]广州中医药大学中药学院,广州510405

出　　处：《中药药理与临床》2004年第6期33-34,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的 :从细胞因子改变与AD的关系探讨养寿丹防治AD的作用机理。方法 :用放射免疫法测定Alzheimer病模型大鼠血清中细胞因子IL 2、IL 6、TNF。结果 :Alzheimer病模型大鼠血清中细胞因子IL 2、IL 6、TNF明显增高 ,其中以TNF和IL 6明显 (P <0 .0 5 ) ;养寿丹能明显降低Alzheimer病模型大鼠血清中过度增高的TNF、IL 6和IL 2。结论 :养寿丹能明显抑制Alzheimer病模型大鼠血清中细胞因子的过度表达 ,抑制Alzheimer病免疫炎症机制中的级联放大效应 ,从而防制Alzheimer病。Objective: To study the mechanism of Yang Shoudan(YSD) on the prevention and treatment of Alzheimer’s Disease(AD) From the relationship between AD and the changes of cytokine. Methods: Radioimmunoassay(RIA) was used to inspect the content of TNF、IL 6、IL 2 in serum of rats and then compared their data between groups. Results: The content of TNF、IL 6 and IL 2 in model rats were much higher than that in NS group ,especially the content of TNF and IL 6. YSD could reduce obviously the content of TNF IL 6 and IL 2,especially. Conclusion: YSD could prevent and treat AD through inhibiting the excessive expression of cytokine in AD rat to restraining its continuous amplification effects in the immune mechanism of inflammation of AD.

关 键 词：ALZHEIMER病 模型大鼠 细胞因子 TNF IL-6 血清 IL-2 降低 抑制 放大效应 

分 类 号：R285[医药卫生—中药学]