川芎嗪对烫伤大鼠消化系统的保护作用  

Protective Effects of Ligustrazine on Digestive System of Buurned Rats

作　　者：朱汉荣[1] 何丽娅[1] 朱蕾[1] 成彩莲[1] 陈勇[1] 赵雪花[1] 吴勉云[1] 夏瑞明[1] 

机构地区：[1]武汉科技大学医学院,湖北武汉430080

出　　处：《武汉科技大学学报》2004年第4期429-430,440,共3页Journal of Wuhan University of Science and Technology

摘　　要：观察烫伤大鼠胃、小肠、肝组织ATP酶(ATPase)、谷胱甘肽过氧化物酶(GSH Px)、丙二醛(MDA)的变化及川芎嗪的防治效果。以健康Wistar大鼠作为模型,分别取胃、小肠、肝组织测定观察值。结果发现,川芎嗪可提高烫伤大鼠胃、小肠和肝组织中ATPase和GSH Px的活性,降低组织中MDA的含量。这说明,川芎嗪可对烫伤后大鼠的胃、小肠、肝组织起到一定的保护作用,其机制可能与减少自由基的产生及直接抗氧化作用有关。To observe the effects of ligustrazine on the contents of ATPase, GSH-Px, MDA in stomach, intestine and liver of severely burned rats,the rats were randomly divided into three groups. Tissues of stomach, intestine and liver were gathered and homogenized respectively, and contents of ATPase, GSH-Px, MDA were assayed.It was found that the contents of ATPase, GSH-Px in stomach, intestine and liver decreased significantly while MDA were obviously enhanced in comparison with that of normal group. After the treatment with ligustrazine, the contents of ATPase, GSH-Px were significantly higher but MDA lower than that of non-treated burned group. So it can be concluded that ligustrazine has protective effects on stomach, intestine and liver in burned rats.This might be because ligustrazine can reduce free radicals and has antioxidant effects on stomach, intestine and liver.

关 键 词：川芎嗪 过氧化脂质 烫伤 

分 类 号：R333[医药卫生—人体生理学]