去淋巴细胞-血浆疗法治疗难治性全身性红斑狼疮  

Lymphoplasmapheresis for Refractory Systemic Lupus Erythematosis

作　　者：刘文励[1] 唐锦治[1] 孙汉英[1] 杨忠心[2] 胡诗学[2] 

机构地区：[1]同济医科大学附属同济医院内科 [2]同济医科大学附属同济医院血库

出　　处：《同济医科大学学报》1993年第1期24-27,共4页Acta Universitatis Medicinae Tongji

基　　金：湖北省卫生厅资助课题

摘　　要：用Haemoneti V_(50)血细胞分离机对22例活动性、难治性全身性红斑狼疮患者进行了103次去淋巴细胞-血浆疗法(LPE),每次平均清除1.12×10~9淋巴细胞,去血浆20～30ml/lg,1～3次开始显效。近期显效17例,有效3例,无效2例。随访12～54月,仍处于缓解14例,最长6例已48～54月。主要并发症是环磷酰胺引起的粒细胞减少症及感染。初步探讨了LPE对SLE免疫功能的影响。Using the Haemonetics Model 50 Blood Processor,103 lymphoplas-mapheresis(LPE) procedures were performed in 22 patients with active and refractory systemic lupus erythematosis (SLE). Approximately 20-30 ml of plasma per kilogram of body weight and a mean of 1.12×108 lymphocytes were removed during each procedure. 1-3 procedures over 2-3 weeks could result in clinical improvement. Among the 22 patients, 17 showed marked improvement, 3 slight improvement,and 2 no signs of improvement. After 1-4 year follow-up observation, 14 cases remained remitted. The major complications 2 patients developed were granulocytopenia and septicaemia induced by immunosuppressive drugs. The effects of LPE on immunologic fucntion of SLE are briefly discussed.

关 键 词：红斑狼疮 免疫 细胞 免疫疗法 

分 类 号：R593.240.5[医药卫生—内科学]