青心酮在家兔体内的药代动力学研究  

Pharmacokinetics of Qingxingtong in Rabbits

作　　者：黎曙霞[1] 李郁[1] 闪珍珍[1] 熊忠明[1] 吴熙瑞[1] 尹小刚[2] 

机构地区：[1]同济医科大学生殖医学中心计划生育研究所 [2]同济医科大学实验医学研究中心

出　　处：《同济医科大学学报》1993年第2期91-92,共2页Acta Universitatis Medicinae Tongji

摘　　要：应用高效液相色谱法研究了青心酮在家兔体内3种给药途径的药代动力学过程,结果表明,家兔静脉注射青心酮符合二室开放模型,肌肉注射和灌胃给药符合单室开放模型。药物的吸收和消除均很迅速,2 h内已基本自体内消除,肌肉注射生物利用度较高,灌胃给药则较低。In the present study the pharmacokinetics of Qingxingtong (3,4 -dihydroxyacetophenone, DHAP) has been performed with HPLC by three administration routes (by intravenous, intramuscular injections and by gavage). Intravenous administration of DHAP is suited for two-compartment open model, while oral or intramuscular route for one-compartment open model. The drug was rapidly absorbed and excreted and almost entirely eliminated from the animal body within 2 h. The bioavailability of DHAP administered by intramascular route is higher than that by oralroute.

关 键 词：青心酮 高效液相色谱 药代动力学 

分 类 号：R969.1[医药卫生—药理学]