恶丙嗪在大鼠体内的药代动力学研究  

A Pharmacokinetic Study of Oxaprozin in Rats

作　　者：石建平[1] 吴熙瑞[1] 朱艳霞[1] 

机构地区：[1]同济医科大学计划生育研究所,武汉430030

出　　处：《同济医科大学学报》1993年第5期336-338,共3页Acta Universitatis Medicinae Tongji

摘　　要：采用高效液相色谱法(HPLC)测定恶丙嗪(Oxaprozin)在大鼠体内的药代动力学参数,测得药物血浆峰浓度(C_(max))46.1μmol/L,达峰时间(T_(max))1.2 h,药物半衰期(t_(1/2))5.4 h,曲线下面积(AUC)492.9 μmol/(L·h)。以胃肠道残留量法计算经口给药后的吸收量,结果给药 12 h后药物吸收量达到给药量的98％以上。测定恶丙嗪不同时间在大鼠各脏器的分布,以肝、肾、胃、肠分布量大,脑和肌肉中分布量少。未见药物在各组织内有明显积蓄。Following an intragastric administration of 50 mg/kg oxaprozin to rats, the drug was rapidly absorbed and assayed by HPLC method. Pharmacokinetic parameters were measured as Tmax 1. 2 h, Cmax 46. 1 μmol/L, t1/2 5. 4 h, AUC 492. 9 μmol/(L · h). Absorption of oxaprozin in rats was investigated with the residual amount method of stomach-intestines. It was found that more than 98 % dosed medicine was absorbed in 12 h after administration. The drug was distributed in larger amounts in the liver, kidneys, stomach and intestines, but in smaller amounts in the brain and muscles.

关 键 词：恶内嗪 抗炎药 非甾体 药代动力学 

分 类 号：R971.1[医药卫生—药品]