2型糖尿病合并高血压病患者尿微量白蛋白患病率研究  

Prevalence of microalbuminuria in type 2 diabetic patients with hypertension

作　　者：关美萍[1] 李晨钟[1] 薛耀明[1] 沈洁[1] 高方[1] 罗祥容[1] 

机构地区：[1]南方医科大学南方医院内分泌科,广东广州510515

出　　处：《第一军医大学学报》2005年第2期234-235,共2页Journal of First Military Medical University

摘　　要：目的调查2型糖尿病合并高血压病患者的微量白蛋白尿患病率。方法采用半定量比色尿试纸测定55例2型糖尿病合并高血压病患者的尿微量白蛋白,计算微量白蛋白尿的发生率。结果2型糖尿病合并高血压病患者正常、微量及大量尿白蛋白的患病率分别为66.67%、22.22%和11.11%。结论2型糖尿病合并高血压病患者中可能有约1/3的患者存在肾病损害,应早期筛查并干预治疗。Objective To investigate the prevalence of microalbuminuria in type 2 diabetic patients with hypertension. Method Urinary albumin excretion was measured in 55 diabetic patients with hypertension by colorimetric methods using commercially available test strips of Nephur 7 and Micro-Ⅱ, the latter test strips employed only when the former yielded negative results for proteinuria. The height, body weight, waist circumference and blood pressure were measured for all the patients with also biochemical examination for serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood glucose and creatinine. HbA1c was determined by Bio-STAT. Results The rates of normal urinary albumin, micro- and macroalbuminuria were 66.67%, 22.22% and 11.11% in these patients, respectively. In patients with a history of diabetes for more than 10 years, the rates were 58.33%, 8.33% and 33.33%, respectively. Conclusion Nearly 1/3 of type 2 diabetic patients with hypertension have microalbuminuria and proteinuria, and screening for microalbuminuria and proper interventions in these patients might prove beneficial.

关 键 词：糖尿病 非胰岛素依赖型 高血压 微量白蛋白 尿分析 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]