放射免疫分析测定Alb、β_2-M和THP诊断中、老年患者肾功能早期损害的价值  

RADIOIMMUNOASSAY OF Alb, β_2-M AND THP THE DIAGNOSTIC VALUE ON EARLY KIDNEY FUNCTION DEGENERATION FOR THE OLD-AND MID-AGED PATIENTS

作　　者：谢植元[1] 李生琪 任树生[1] 陈玉英 

机构地区：[1]天津市第三医院天津市老年医学研究所 300250

出　　处：《同位素》1993年第3期178-182,共5页Journal of Isotopes

摘　　要：β_2-微球蛋白(β-2-M)、丝状糖蛋白(THP)、白蛋白(Alb)和免疫球蛋白G(IgG)联合检测可作为肾功能减退早期诊断的灵敏指标。文章观察107例,明显的得出β_2-M和尿THP(UTHP)的异常检出率分别为50.75%和65.67%,比肌酐清除率(C_(cr))异常检出率要高出1.5—2.3倍。放免检测β_2-M和THP方法比C_(cr)更能早期发现轻度的肾功能损害,其临床价值显然优于传统检测项目及经典方法。人体任何系统疾病都可通过不同机制影响肾脏功能,中老年人肾组织退行性改变导致肾功能下降尤为关注。肾脏功能异常检出率以β_2-M和THP的重吸收率为最高,其次为尿Alb。The combined determination of β_2-M, THP, Alb, IgG may be used as the sensitive indication of the early degeneration of kidney function. The paper observed 107 cases, and found that the anomalous examine-out ratios of haemorrhage β_2-M and UTHP are 50.75% and 65.67% respectively, 1.5—2.3 times higher than the C_(cr) anomals examine-out ratio. The radio-immunoassay of β_2-M and THP is a better measure for discovering light kidney function injury in early period than C_(cr) method. The clinical value of the radio-immunoassay of β_2-M, THP is obviously better than the traditional and classical method. The diseases of anybody system may influence the kidney function through various mechanisms. The retrogression of kidney tissue of the patients in old-and mid-age leads to decrease of kidney function. The combination of β_2-M and THP has the highest anomalous examine-out ratios of kidney function; the next is urine Alb.

关 键 词：糖蛋白 球蛋白 放射免疫测定 肾 

分 类 号：R817.4[医药卫生—影像医学与核医学]