雷公藤贴剂透皮吸收示踪研究  

A STUDY ON TRIPTERYGIUM WILFORDⅡ PATCHER WITH RADIOISOTOPE TRACING TECHNIQUE

作　　者：沈子龙[1] 修艳霞 程天贵 

机构地区：[1]中国药科大学生物技术中心,南京210009

出　　处：《同位素》1993年第3期158-162,共5页Journal of Isotopes

摘　　要：雷公藤是一种对某些疾病有独特疗效的中草药。临床上主要用于治疗风湿性关节炎,也可用于肿瘤和炎症的治疗。但目前市售产品是片剂,口服后毒性高,副作用十分严重,因此它的应用受到限制。为此,我们研制了雷公藤透皮制剂,以提高疗效和减少毒副作用。用雷公藤的有效成分之一——雷公藤甲素的~3H标记物作示踪剂,研究了雷公藤甲素的渗透速率;不同剂量对大鼠血液中雷公藤甲素浓度的影响;贴用雷公藤后,皮肤和肌肉中雷公藤甲素的含量;不同含量的促渗剂Azone(氮酮)对雷公藤甲素透皮速率的影响和雷公藤甲素经皮吸收速率。Tripterygium wilfordii is a traditional Chinese drug. It has special effect on some diseases, such as rheumatic arthritis, tumors and some inflammation. But it has some toxicity effect. Tripterygium wilfordii patcher in order to avoid its oral toxicity effect is prepared. The permeability through skin, release in vitro, effect of doses on concentration in blood and average rate of percutaneous absorption in vivo and effect of Azone on permeability through skin with radioisotope tracer are described.

关 键 词：雷公藤 透皮吸收 示踪法 吸收 

分 类 号：R817.5[医药卫生—影像医学与核医学]