左旋卡尼汀对异丙肾上腺素致心肌损害的影响  

Protective effect of L-carnitine on myocardial damage induced by isoproterenol

作　　者：钱伟[1] 殷仁富[1] 任建平[2] 顾书华 

机构地区：[1]第二军医大学长征医院心内科,上海200003 [2]军事医学科学院二所,北京100850 [3]常州三维工业技术研究所,江苏常州213022

出　　处：《心脏杂志》2005年第1期13-15,共3页Chinese Heart Journal

摘　　要：目的:观察左旋卡尼汀对异丙肾上腺素致心肌损害的保护作用并探讨其机制。方法:采用大鼠皮下注射异丙肾上腺素造成心肌损害模型。心肌切片,HE染色,光镜下观察心肌损害程度;分离心肌线粒体,测定膜脂流动性(LFU)。结果:注射左旋卡尼汀可减轻心肌损害程度;改善线粒体的损伤,改善LFU。结论:左旋卡尼汀能减轻异丙肾对心肌的损害,对线粒体膜脂流动性损伤具有明显的保护作用。AMI: To investigate the protective effect of L-carnitine on myocardial damage induced by isoproterenol and its mechanism. METHODS: Rat myocardial ischemia was induced by isoprenaline(ISO) 5 mg/kg injected subcutaneously. Sections of heart were stained with hematoxylin eosin and the degree of myocardial damage was evaluated under the microscope. Rat myocardial mitochondria were isolated, and membrane lipid fluidity (LFU) was determined. RESULTS: The degree of myocardial damage was significantly reduced in the groups treated and pretreated with L-carnitine. Injury of myocardial mitochondra was attenuated in the L-carnitine group. CONCLUSION: L-carnitine may protect the myocardium from damage by isoproterenol and may also have protective effect on LFU of mitochondria damaged by ISO.

关 键 词：左旋卡尼汀 异丙肾上腺素 线粒体 膜脂流动性 

分 类 号：R541.6[医药卫生—心血管疾病]