Increased expression of aquaporin-4 in human traumatic brain injury and brain tumors  

作　　者：胡华 姚洪田 张纬萍 张磊 丁伟 张世红 陈忠 魏尔清 

机构地区：[1]Department of Neurosurgery,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou310009,China Department of Pharmacology.School of Medicine,Zhejiang University,Hangzhou310031,China [2]Department of Pathology,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou310003,China [3]Department of Neurosurgery,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou310009,China [4]Department of Neurosury,Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou310009,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2005年第1期33-37,共5页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：ProjectsupportedbytheNationalNaturalScienceFoundationofChina(No.30271498)theNationalBasicResearchRrogram(973)ofChina(No.G1999054000)

摘　　要：Objective:To characterize the expression of aquaporin-4(AQP4),one of the aquaporins(AQPs),in human brainspecimens from patients with traumatic brain injury or brain tumors.Methods:Nineteen hnman brain specimens were obtahledfrom the patients with traumatic brain injury,brain tumors,benign meningioma or early stage hemorrhagic stroke.MRI or CTimaging was used to assess brain edema.Hematoxylin and eosm staining were used to evaluate cell damage,Immunohistochem-istry was used to detect the AQP4 expression.Results:AQP4 expression was increased from 15 h to at least 8 d after injury.AQP4immunoreactivity was strong around astrocytomas,ganglioglioma and metastatic adenocarcinoma.However,AQP4 immunore-activity was only found in the centers of astrocytomas and ganglioglioma,but not in metastatic adenocarcinoma derived from lung.Conclusion:AQP4 expression increases in human brains alter traumatic brain injury,within brain-derived tumors,and aroundbrain tumors.Objective: To characterize the expression of aquaporin-4 (AQP4), one of the aquaporins (AQPs), in human brain specimens from patients with traumatic brain injury or brain tumors. Methods: Nineteen human brain specimens were obtained from the patients with traumatic brain injury, brain tumors, benign meningioma or early stage hemorrhagic stroke. MRI or CT imaging was used to assess brain edema. Hematoxylin and eosin staining were used to evaluate cell damage. Immunohistochemistry was used to detect the AQP4 expression. Results: AQP4 expression was increased from 15h to at least 8 d after injury. AQP4immunoreactivity was strong around astrocytomas, ganglioglioma and metastatic adenocarcinoma. However, AQP4 immunoreactivity was only found in the centers of astrocytomas and ganglioglioma, but not in metastatic adenocarcinoma derived from lung.Conclusion: AQP4 expression increases in human brains after traumatic brain injury, within brain-derived tumors, and around brain tumors.

关 键 词：Aquaporin-4(AQP4) Traumatic brain injury ASTROCYTOMA GANGLIOGLIOMA Metastatic adenocarcinoma Brain edema 

分 类 号：R651.1[医药卫生—外科学]