天麻对大鼠肾缺血再灌注损伤中SOD、MDA作用的研究  

Antioxidation Effect of Rhizoma Gastrodiae on Rat Renal Ischemia/reperfusion Model

作　　者：刘凌钊[1] 邓慧[1] 陈婉辉[1] 陈嘉元[1] 王志明[1] 张奕炜[1] 董晓先[2] 梁仲培[2] 

机构地区：[1]广州医学院临床一系2001级3班 [2]广州医学院病理生理学教研室,广州510182

出　　处：《现代临床医学生物工程学杂志》2004年第6期479-481,共3页Journal of Modern Clinical Medical Bioengineering

摘　　要：目的　探讨天麻在大鼠肾缺血再灌注损伤中的抗氧化作用 .方法　通过建立大鼠急性肾缺血再灌注损伤模型 ,测定天麻对肾缺血再灌注后肾组织SOD活力与MDA含量的变化 .结果　与对照组相比 ,使用天麻后 ,在再灌注 6h、12h和 2 4h后肾组织SOD活力明显升高 (p值分别 <0 .0 1,0 .0 5 ,0 .0 1) ,MDA含量明显降低 (p值分别 <0 .0 5 ,0 .0 1,0 .0 5 ) .结论　天麻在大鼠肾缺血再灌注损伤模型中 ,有抗自由基损伤和减轻脂质过氧化的作用 .Objective To study the anti-oxidant effects of Rhizoma Gastrodiae on rat models with renal ischemia reperfusion injuries. Methods Rhizoma Gastrodiae was administered intraperitoneally into rat for every 6 hours beginning from 2 days before surgery until 1,6,12 and 24 hours after reperfusion .At 1, 6, 12 and 24 hours after reperfusion, SOD and MDA in renal tissues were analyzed. Results 6, 12 and 24 hours after reperfusion, the kidney SOD activities were significantly increased (p<0.01 p<0.05 and p<0.01, respectively) ,while the concentration of renal MDA significantly decreased (p<0.05.p<0.01 and p<0.05. respectively). Conclusion Rhizoma Gastrodiae may have preventive role in renal ischemia reperfusion injury, possibly through anti-oxidative actions against free radicals and lipid peroxides.

关 键 词：天麻 大鼠 肾 缺血再灌注损伤 

分 类 号：R285[医药卫生—中药学]