IL-6和TNF-α在Graves病的改变  

The Change of Serum Level of IL-6 and TNF-α in Patients with Graves Disease

作　　者：沈静雪[1] 刘英敏[2] 田坚[1] 

机构地区：[1]沈阳医学院附属中心医院内分泌科,辽宁沈阳110024 [2]中国医科大学附属二院内分泌科

出　　处：《中国医师杂志》2004年第12期1640-1641,共2页Journal of Chinese Physician

摘　　要：目的　探讨IL -6、TNF -α在Graves病 (GD)中的改变。方法　 3 7例GD患者在治疗前和缓解后测定血清IL -6、TNF-α水平 ,3 0例志愿者作为正常对照。结果　治疗前GD患者血清IL -6、TNF -α显著高于对照组 (P <0 0 1) ;缓解后IL -6降至正常 (P >0 0 5 ) ,但TNF -α仍高于正常 (P <0 0 1) ;治疗前GD患者血清IL -6与FT3、FT4呈正相关 ,而TNF -α与FT3、FT4无相关。结论　GD患者血清IL -6、TNF -α的变化可能与GD的发生发展有关。Objective To investigate the change of serum level of IL-6 and TNF-α in patients with Graves disease(GD). Methods Serum IL-6 and TNF-α levels of 37 GD patients before and after treatment were measured. And 30 healthy subjects served as controls. Results Serum levels of IL-6 and TNF-α in GD patients before treatment were significantly higher than those in the controls(P<0.01), serum level of IL-6 in GD patients after treatment decreased to normal range, but serum TNF-α level in GD patients after treatment was still higher than that in the controls(P<0.01). There was a positive correlation between serum IL-6 level and FT 3,FT 4 levels before treatment, but no correlation between serum TNF-α level and FT 3,FT 4 levels. Conclusion The change of serum IL-6 and TNF-α levels might be related with the pathogenesis of GD.

关 键 词：TNF-Α GD 血清IL-6 患者 治疗前 正常 改变 结论 志愿者 水平 

分 类 号：R581.1[医药卫生—内分泌]