B超引导下经皮脾穿刺注射无水酒精治疗脾功能亢进症的研究  

Percutaneous Splenic Puncture with Dehydrated Alcohol Injection Guided by Ultrasound in Hypersplenism

作　　者：武建军[1] 苏内林[1] 李敏[1] 秦二平[1] 石福鲜[1] 陈英[1] 潘晓明[1] 

机构地区：[1]内蒙古自治区医院消化内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2004年第12期1003-1004,共2页Inner Mongolia Medical Journal

基　　金：内蒙古自治区科技厅自然科学基金资助项目;项目编号 :2 0 0 30 80 2 0 6 17

摘　　要：目的 :评价B超引导下经皮脾穿刺无水乙醇注射治疗脾功能亢进合并门脉高压征的有效性和安全性。方法 :2 8例患者接受治疗 ,脾内分点注射无水乙醇 ,1次注射总量可达 16～ 18ml,每周 1～ 2次 ,血小板上升到 5 0× 10 9/L后 ,注射停止。检测治疗前后外周血中血小板和白细胞值。B超测定脾脏体积指数和肝门脉内径。结果 :治疗前后外周血小板和白细胞值有显著性差异 (P <0 0 1,P <0 0 5 ) ,门脉内径宽度则明显低于治疗前 (P <0 0 1)。结论 :经皮脾穿刺无水乙醇注射引起脾组织局灶坏死 ,其作用相当于部分脾切除 ,故能显著改善门脉高压和脾功能亢进 ,且安全、方便、经济 。Objective:To evaluate the effectiveness and safety of percutaneous splenic puncture with dehydrated alcohol injection in patients with hypersplenism combined with portal hypertension.Methods:28 patients underwent the treatment with injection of dehydraed alcohol in several different periphery spot of spleens,16 to 18ml in a dose,once to twice a week until peripheral thrombocyte reached to 50×10 9/L.The numer of peripheral thrombocyte and leukocyte was determined before and after treatment.The volume index of spleen and inner diameter of hepatic portal vein were measured by ultrasonography.Results:The number of peripheral thrombocyte and leukocyte was significantly different before and after treatment(P<0.01,P<0.05).The inner diameter of hepatic portal vein after treatment was lower than that before treatment(P<0.01).Conclusion:Percutaneous splenic puncture with dehydrated alcohol injection results in focal necrosis of spleen,which equal to partical splenectomy.It is an feasible,safe and economic methods.The technique should be clinically recommended.

关 键 词：脾穿刺 无水酒精 脾功亢进 

分 类 号：R445.12[医药卫生—影像医学与核医学] R657.63[医药卫生—诊断学]