冠心病人P-选择素、血管性血友病因子、CRP的变化及意义  

Change of Ps, vWF, CRP levels and its meaning in patients with coronary artery disease

作　　者：邢俊杰[1] 张湘兰[1] 

机构地区：[1]沈阳医学院附属第二医院心内科,辽宁沈阳市110002

出　　处：《心血管康复医学杂志》2005年第1期31-33,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察冠心病人P-选择素(P-selection,Ps)、血管性血友病因子(vWF)和C-反应蛋白(CRP)浓度的变化;探讨血小板活化、血栓形成及炎症反应在冠心病发病中的作用。方法:测定21例急性心肌梗死(AMI)、29例不稳定型心绞痛(UAP)病人和203例正常人的Ps、vWF、CRP,并对AMI、UAP患者行冠状动脉造影,作比较分析。结果:AMI、UAP病人血浆Ps、vWF、CRP水平明显升高(P<0.01)。冠脉三支病变组的Ps水平明显高于单支和双支病变组(P<0.01)。结论:血小板活化及炎症反应参与冠心病发病,其程度与冠心病严重程度相关。Objective: To study the change of P -selection (Ps), van Willebrand factor (vWF), C -reaction protein (CRP) and its meaning in patients with coronary artery disease. Methods: The concentrations of plasma Ps, vWF, CRP were measured in 21 patients with acute myocardlal infarction (AMI), 25 patients with unstable angina pectons (UAP) and 203 normal persons. Results: Results: The concentrations of plasma Ps, vWF, CRP in AMI and UAP patients were significantly higher than that of normal persons (P<0. 01). The level of Ps increased in three branches lesion group compared with single and two branches lesion group (P<0. 01). Conclusion: The platelet activation and inflammatory reaction may play an important role in the pathogenesis of CAD.

关 键 词：CRP P—选择素 冠心病人 UAP 血管性血友病因子 血小板活化 炎症反应 发病 AMI 人血浆 

分 类 号：R541.4[医药卫生—心血管疾病] R542.22[医药卫生—内科学]