慢性心衰患者的血管内皮功能不全及其临床意义  

Clinical significance of endotheiial disfunction in chronic heart failure

作　　者：黄红漫[1] 孙晓兰[1] 许其倓[1] 

机构地区：[1]上海市杨浦区市东医院,上海市200090

出　　处：《心血管康复医学杂志》2005年第1期33-35,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究心衰患者治疗前、后血管内皮功能的变化。方法:常规测定80例心功能不全患者治疗前、后一氧化氮(NO)、内皮素(ET)、血管紧张素Ⅱ(AngⅡ)、血流介导的内皮依赖性血管舒张功能及心功能变化。结果:治疗后,随着心功能的改善,NO水平上升,ET、AngⅡ水平下降,(P<0.01),血流介导的内皮依赖性舒张功能明显改善(P<0.05)。结论:心力衰竭患者的内皮功能随着心衰程度的改善而改善。Objective: To investigate the changes of endothelial function in chronic heart failure. Methods: The levels of nitrous oxide (NO), endothehn (ET), angiotension Ⅱ (Ang Ⅱ ) and flow-mediated dilation were detected after treatment in 80 patients with chronic heart failure. Results: Following the change of cardiac function after treatment, the level of NO increased significantly (P<0. 01), ET, Ang Ⅱ decreased significantly (P<0. 01) and flow-mediated dilation function improved (P<0. 05). Conclusion: Endothelial function is improving following the cardiac function improved in patients with chronic heart failure.

关 键 词：患者 治疗前 血管内皮功能不全 血流介导 慢性心衰 心功能 临床意义 内皮依赖性舒张功能 治疗后 内皮素(ET) 

分 类 号：R541[医药卫生—心血管疾病] R543[医药卫生—内科学]