苯那普利对肾性高血压大鼠心率变异的影响  

Effects of benapril on heart rate variability in rats with renal hypertension/Z

作　　者：赵金晶[1] 邢俊杰[1] 冯旭辉[2] 李亘松[2] 

机构地区：[1]沈阳医学院附属第二医院心内科,辽宁沈阳110002 [2]中国医科大学生理学教研室

出　　处：《心血管康复医学杂志》2005年第1期40-42,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨苯那普利对肾性高血压大鼠降压同时对心率变异的影响。方法:制备肾性高血压大鼠模型,给予苯那普利治疗,分析其心率变异(HRV)的变化,并测定大鼠血浆血管紧张素Ⅱ(AngⅡ)的浓度。结果:高血压鼠血浆AngⅡ水平明显升高,心率变异时域指标中SDNN(全程记录期间所有窦性心搏R-R间期的标准差).rMSSD(相邻R-R间期差值的均方根)明显降低,频域指标中TP(总功率谱),VLF(极低频功率谱),LF(低频功率谱),HF(高频功率谱)明显降低,LF／HF(低高频比值)升高,P均<0.01;治疗后SDNN.rMSSD,TP,HF明显提高,LF／HF明显降低,P均<0.01。结论:苯那普利降压同时可改善自主神经调节功能。Objective: To explore the effects of benapril on heart rate variability (HRV)in rats with renal hypertension. Methods: Made the rats model with renal hypertension, then administrated them benapril to decrease the blood pressure , then analyzed HRV with the special software ; and measured the plasma level of angiotensin Ⅱ . Results: The plasma level of angiotensin Ⅱ in renal hypertensive rats increased significantly; SDNN. rMSSD, TP, VLF, LF, HF decreased significantly and LFHF increased significantly, P<0. 01 all; After the treatment of benapril, SDNN, rMSSD, TP, HF increased significantly and LFHF ratio decreased, P<0. 01 all. Conclusion: The treatment of benapril plays an important role not only in reducing the blood pressure but also in improving the autonomic nervous function.

关 键 词：苯那普利 心率变异 肾性高血压 大鼠模型 血浆 降压 治疗后 TP 自主神经 窦性心搏 

分 类 号：R544[医药卫生—心血管疾病] R541[医药卫生—内科学]