经腰穿注入尿激酶治疗脑池血肿  

Treatment of intracisternal hematoma by lumbar puncture and urokinase infusion

作　　者：王文浩[1] 杨少春[1] 陈文彬[1] 林国文[1] 

机构地区：[1]福建省漳州市解放军第一七五医院神经外科,363000

出　　处：《中华神经医学杂志》2005年第2期170-171,共2页Chinese Journal of Neuromedicine

摘　　要：目的探讨腰穿注入尿激酶治疗脑池血肿的疗效。方法将67例创伤性蛛网膜下腔出血并脑池血肿的病人,随机分成两组:A组,35例,单纯腰穿放脑脊液治疗;B组,32例,在腰穿放脑脊液基础上注入尿激酶治疗。疗效比较:(1)在伤后第7天、第15天复查头颅CT,分别比较两组病例的恢复例数,并行χ2检验;(2)比较两组病例治愈所行腰穿次数,并行t检验。结果经腰穿放液注入尿激酶疗效明显优于单纯腰穿放液,统计学检验均存在显著性差异(P<0.01)。结论该方法是一种简单有效且安全的治疗脑池内血肿的新方法。Objective To evaluate curative effect of intracisternal hematoma by infusing urokinase through lumbar puncture. Methods 67 cases with traumatic subarachnoid hemorrhage complicated with intracisternal hematoma were randomly divided into Group A and Group B. In Group A, 35 cases were treated by simple lumbar puncture to discharge cerebrospinal fluid and in Group B, 32 cases were treated by simple lumbar puncture to discharge cerebrospinal fluid and urokinase infusion simultaneously. (1) The number of recovered cases in the 2 groups was compared by means of χ2 text according to cranial CT re-examination results at day 7 and 15 after injury.(2) Times for lumbar puncture in the 2 groups were compared also by t-test. Results Statistically, the therapies between the two had significant differences and the curative effect of urokinase infusion through lumbar puncture was better evidently than that of simple lumbar puncture(t=3.57, P<0.001; χ2=10.77?8.31, P<0.01). Conclusion Infusion of urokinase by lumbar puncture, as a novel therapy to treat intracisternal hematoma, is simple, efficient and safe.

关 键 词：治疗 脑池 血肿 尿激酶 腰穿放脑脊液 注入 疗效 恢复 T检验 

分 类 号：R651.15[医药卫生—外科学]