老年高血压合并动脉粥样硬化患者主动脉僵硬度的临床研究  

Clinical study of arterial stiffness in aged patients with essential hypertension and atherosclerosis

作　　者：张志勉[1] 胡利芳 梁济乐[1] 高西美[1] 米丰花[1] 陈珉[1] 

机构地区：[1]山东大学齐鲁医院健康体检中心,山东济南25012 [2]山东电力中心医院神经内科

出　　处：《山东大学学报（医学版）》2005年第1期57-59,62,共4页Journal of Shandong University:Health Sciences

基　　金：山东省科委科研基金资助项目(2002BB1CJA11)

摘　　要：目的:探讨老年高血压(EH)合并动脉粥样硬化患者主动脉僵硬度的改变及其相关因素。方法:98例老年高血压病患者,男69例,女29例,63～87岁,平均(65.42±10.78)岁。应用脉搏波传导速度(PWV)自动测量系统测定颈动脉-股动脉,PWV作为反映主动脉僵硬度的参数;B型超声对颈动脉进行扫查,动脉粥样硬化的定义为内膜-中层厚度≥1.3mm。结果:EH合并颈动脉粥样斑块患者38例,与未合并颈动脉粥样硬化患者相比,EH合并颈动脉粥样硬化患者收缩压犤(149.93±18.25)/(141.12±20.10)mmHg犦、PWV〔(12.36±2.12)/(10.49±2.76)m/s〕显著升高(P<0.001)。多元逐步回归分析结果表明,年龄、收缩压与反映主动脉僵硬度的PWV关系密切(P<0.001)。结论:老年高血压合并颈动脉粥样硬化患者主动脉僵硬度增加,年龄和收缩压与患者主动脉僵硬度密切相关。Objective: To explore the changes of arterial stiffness and their relative factors in aged patients with essential hypertension and atherosclerosis. Methods: Ninety-eight hypertensive patients,aged 63～87 (aver age 65.42±10.78) years,69 male,29 female were selected. Automatic pulse wave velocity(PWV) system was applied to examine carotid-femoral PWV reflecting arterial stiffness .B-mode ultrasound was used to scan carotid artery. Whose common carotid artery intima-media thickness≥1.3mm was defined as atherosclerosis. Results: Among 98 patients with EH,38 presented carotid atherosclerosis. Systolic blood pressure was 149.93±18.25 vs 141.12±20.10 mm Hg,PWV was 12.36±2.12 vs 10.49±2.76m/s,which were significantly higher in EH patients with carotid atherosclerosis (P<0.001). Mutivariate regressive analysis demonstrated that age and systolic blood pressure had close relationship with PWV(P<0.001). Conclusions: Aged hypertension and atherosclerosis can increase the arterial stiffness which is closely related with age and systolic blood pressure.

关 键 词：高血压 动脉硬化 主动脉 脉搏波传导速度 老年人 

分 类 号：R541.3[医药卫生—心血管疾病]