血清TNF-α、STNFRI、IL-10、TGF-β_1水平与充血性心力衰竭心功能状态的相关性研究  

Correlation of serum TNF-α,STNFRI,IL-10,TGF-β_1 and cardiac function in congestive heart failure

作　　者：刘向群[1] 刘传亮[2] 谭洪勇[1] 

机构地区：[1]山东大学齐鲁医院干部保健科,山东济南250012 [2]潍坊市人民医院干部病房,山东潍坊261041

出　　处：《山东大学学报（医学版）》2005年第1期72-74,共3页Journal of Shandong University:Health Sciences

基　　金：山东省科技厅立项课题(1999BB1CJA1)

摘　　要：目的:探讨充血性心力衰竭(CHF)患者血清肿瘤坏死因子α(TNF-α)、可溶性肿瘤坏死因子受体I(STNFRI)、白细胞介素10(IL-10)和转化生长因子β1(TGF-β1)的动态变化。方法:应用双抗体夹心ELISA法测定56例充血性心力衰竭(CHF)患者和30例健康对照者的血清TNF-α、STNFRI、IL-10、TGF-β1的水平。结果:与对照组比较,心力衰竭患者血清TNF-α、STNFRI、IL-10、TGF-β1水平明显增高(P<0.01),TNF-α/STNFRI与TNF-α/IL-10显著增高(P<0.05,P<0.01)。结论:心力衰竭患者血清炎症性细胞因子过度激活,其水平与心功能状态密切相关。Objective: To investigate the changes of serum levels of TNF-α,STNFRI,IL-10 and TGF-β1 in CHF patients with different classes of cardiac function. Methods: The severe levels of serum TNF-α,STNFRI,IL-10 and TGF-β1 were determined by ELISA in 56 patients with moderate to congestive heart failure (CHF) and 30 healthy subjects. Results: Compared with matched controls,CHF patients had significantly elevated serum levels of TNF-α,STNFRI,IL-10 and TGF-β1 (P<0.01). TNFα/STNFRI and TNFα/IL-10 were also notably elevated in these patients (P<0.05,P<0.01). Conclusion: There is enhanced activation of inflammatory cytokines in CHF and the levels of these cytokines are closely related with cardiac function of CHF.

关 键 词：心力衰竭 充血性 肿瘤坏死因子α 可溶性肿瘤坏死因子受体I 白细胞介素10 转化生长因子β1 

分 类 号：R541.61[医药卫生—心血管疾病]