肺撞击伤动物模型的建立  

Establishment of an Animal Model of Lung Impact Injury

作　　者：吴秋平[1] 蒋耀光[2] 闵家新[1] 何家庆[2] 

机构地区：[1]第三军医大学新桥医院胸外科,重庆400037 [2]第三军医大学大坪医院胸外科,重庆400042

出　　处：《中国比较医学杂志》2005年第1期29-31,共3页Chinese Journal of Comparative Medicine

摘　　要：目的　建立声门紧闭状态下肺撞击伤的实验动物模型。方法　以不同驱动压和压缩量撞击 10 8只新西兰兔右侧胸部 ,造成闭合性胸部创伤。结果　不同撞击条件可引起不同程度的胸部创伤 ,肺撞击伤的严重程度与驱动压和撞击压缩量成正相关关系 ,声门紧闭状态下撞击致兔肺撞击伤的AIS分值显著高于声门开放状态下的AIS分值 (P <0 0 5～ <0 0 1)。结论　所建立肺撞击伤动物模型操作简便 ,致伤撞击参数可控 ,且具有重复性 ,可引起不同程度的肺撞击伤 ,病变典型 ,因此可做为研究胸部创伤的较理想的实验动物模型。Objective To develop an experimental animal model of lung impact injury under the closure of glottis. Methods 108 rabbits were impacted in the right chest with various driving pressures and compression percentage resulting in closed thoracic trauma. Results Different impact conditions caused different degrees of thoracic trauma. The severity of lung injury was positively related with the driving pressure and compression percentage. AIS values of the glottis closure group were significantly higher than those of the open group (P<0.05-0.01). Conclusion The established model is relatively simple, easily controllable and highly repeatable, which could be used as a feasible model for the study of thoracic trauma.

关 键 词：撞击伤 实验动物模型 声门 闭合性胸部创伤 严重程度 状态 病变 正相关关系 压缩量 操作 

分 类 号：R655[医药卫生—外科学] R782.6[医药卫生—临床医学]