盐酸哌甲酯的经皮渗透特性研究  

Transdermal characteristics of methylphenidate hydrochloride

作　　者：俞媛[1] 陈琰[1] 张智艳[2] 高申[1] 丁雪鹰[1] 

机构地区：[1]第二军医大学药学院药剂学教研室,上海200433 [2]长海医院药学部

出　　处：《第二军医大学学报》2005年第2期189-191,共3页Academic Journal of Second Military Medical University

基　　金：上海-SK研究与发展基金(2004011 h)

摘　　要：目的:考察盐酸哌甲酯的体外经皮渗透特性. 方法:采用Franz扩散池,裸鼠离体皮肤作为透皮模型,HPLC法测定药物透皮浓度.计算药物在不同浓度(10～100 mg·ml-1)条件下经皮渗透稳态流量、渗透系数以及透皮时滞,并考察几种促透剂(氮酮、N-甲基-2-吡咯烷酮、丙二醇、油酸)对哌甲酯透皮行为的影响.结果:盐酸哌甲酯的经皮渗透稳态流量随浓度增加显著增强(P<0.01),浓度大于50 mg·ml-1时其渗透系数有所增加(P<0.05).8%氮酮和5%丙二醇对药物促透作用明显(P<0.01). 结论:药物浓度、不同促透剂及其浓度对盐酸哌甲酯的经皮渗透有一定的影响.Objective:To investigatethe transdermal delivery characteristics of methylphenidate hydrochloride (MPH) in vitro. Methods: Characteristics of MPH crossing nude rats skin were studied with Franz diffusion cells. A high performance liquid chromatographic (HPLC) method was established to determine the concentration of MPH crossed the skin. The permeability coefficient (P), steady state flux (J) and lag time(LT) for MPH through the skin of nude rats treated with various enhancers were compared with those of control. Results: The permeability coefficient increased with the increase of MPH concentration. The penetration of MPH through nude rats skin was obviously enhanced by 8%Azone and 5%propylene glycol (P< 0.01). Conclusion: Transdermal absorption of MPH can be affected by the concentration of drug and various penetration enhancers.

关 键 词：盐酸哌甲酯 透皮 促透剂 

分 类 号：R985[医药卫生—药品]