腹腔注射胰岛素或其B链肽对NOD小鼠胰岛TNF/TNFR1系统表达的影响  

Expression of TNF/TNFR1 system in islets of NOD mice immunized by insulin or its B chain peptide

作　　者：孙辽[1] 兰丽珍[1] 邓华聪[2] 张志利[1] 刘云峰[1] 肖彧君[2] 赵同峰[2] 

机构地区：[1]山西医科大学第一医院内分泌科 [2]重庆医科大学附属一院内分泌科

出　　处：《中华内分泌代谢杂志》2005年第1期77-78,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目(30070356 );山西省自然科学基金资助项目(20021103)

摘　　要：　以胰岛素或其B链肽 (9 23)免疫 4周龄NOD小鼠,可下调胰腺干扰素γ、肿瘤坏死因子(TNF) α、TNF受体 1 (TNFR1 )、CPP32mRNA表达,下调胰岛细胞及浸润的炎症细胞TNF α、TNFR1、CPP32蛋白表达,减轻胰岛炎程度,降低糖尿病发病率。Four week old NOD mice were immunized by insulin or its B chain peptide (9 23). This procedure down regulated the expression of interferon γ, turmor necrosis factor (TNF) α, TNF receptor 1 (TNFR1) and CPP32 mRNA in pancreas, down regulated the expression of TNF α, TNFR1 and CPP32 proteins in islets and inflammatory cells, attenuated the degree of insulitis and decreased the diabetic incidence.

关 键 词：TNFR NOD小鼠 胰岛素 CPP32 腹腔注射 蛋白表达 TNF受体 胰岛细胞 mRNA表达 

分 类 号：R587.1[医药卫生—内分泌]