非经典的蛋白质分泌途径  

Non-classical Secretory Pathway

作　　者：刘刚[1] 王清明[1] 陈惠鹏[2] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850 [2]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2005年第1期53-55,共3页Letters in Biotechnology

基　　金：国家自然科学基金项目(30170205)

摘　　要：蛋白质分泌是细胞间进行信息传递的重要方式之一。一般的分泌蛋白在其N端都具有信号肽序列,可以通过经典的内质网-高尔基体途径进行运输,并最终分泌到细胞外。近来发现细胞内存在另一类分泌蛋白,它们能够分泌到细胞外发挥功能,但却没有典型的信号肽序列,被称为非经典分泌蛋白。越来越多的证据表明,这类蛋白质的分泌有其独特的机制。本文综述了这类蛋白质的各种分泌机制及可能的生理意义。Secretory proteins play important roles in intercellular communication. The classical secretory protein, which contains a typical signal peptide, is transported through ER-Golgi route. Recently many proteins with a defined extracellular function but lacking signal peptide have been identified and are called non-classical secretory proteins. Increasing evidence shows that the specific mechanisms must be existed for the secretion of the non-classical secretory protein. In this paper, the various secretory mechanisms of the non-classical secretory proteins and the hypotheses on the necessity or advantages of the non-classical secretion were discussed.

关 键 词：非经典分泌蛋白质 信号肽 分泌机制 生理学意义 细胞间信息传递 

分 类 号：Q51[生物学—生物化学] Q249