52例抗着丝点抗体阳性患者临床分析  

The Clinical Analysis of 52 cases with Anticentromere Antibodies

作　　者：高明[1] 谭爱国[2] 刘爱华[1] 谢志贤[2] 

机构地区：[1]卫生部北京医院免疫内科,北京100730 [2]卫生部北京医院检验科免疫室,北京100730

出　　处：《中国实验诊断学》2005年第1期61-63,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　进一步探讨抗着丝点抗体 (ACA)检测的临床意义。方法　对 5 2例ACA阳性患者进行临床回顾性分析。结果　抗着丝点抗体阳性可在多种疾病中出现 ,其中包括系统性硬化征 ,局限性硬度病 ,CREST综合征 ,系统性红斑狼疮 ,类风湿性关节炎 ,干燥综合征 ,雷诺现象 ,重症肌无力 ,重叠综合征 ,原发性胆汁性肝硬化 ,慢性丙型肝炎和自身免疫性肝炎。ACA阳性患者可同时出现类风湿因子 ,多种核型的抗核抗体、抗线粒体抗体 ,抗心磷脂抗体和多种类型的抗ENA抗体。雷诺现象为ACA阳性患者主要临床表现。结论　ACA并非系统性硬化征局限型CREST亚型的特异性抗体 ,ACA阳性时 ,必须结合患者临床症状进行诊断。Objective To further investigate the clinical significance of anticentromere antibodies. Methods 52 patients with positive anticentromere antibodie were clinically retrospected. Results Anticentromere antibodies could exist in many kinds of diseases, including systemic sclerosis, localized sclerosis, CREST syndrom, systemic lupus erythmatosus, rheumatoid arthritis, Sjogren's syndrom, myasthenia gravis, overlap syndrom, primary billiary cirrhosis, chronic hepatitis C and autoimmune hepatitis. Anticentromere antibodies could coexist with several pattems of antinuclear antibodies, anti mitochondria antibody, anti cardiolipid antibody and several kinds of anti ENA antibodies and so on. Raynaud's syndrome is the major clinical characteristic of patients with positive anticentromere antibodie. Conclusion Anticentromere antibody is not specific for the CREST syndrome. If anticentromere antibody is positive, it is still necessary to make the diagnosis by considering the clinical characteristics of patients on the same time.

关 键 词：抗着丝点抗体 系统性硬化征 CREST综合征 雷诺现象 

分 类 号：R593.2[医药卫生—内科学]