^(99)Tc^m-HL91在心肌活性检测中的应用  

An experimental study of ^(99)Tc^m-HL91 in detection of myocardial viability

作　　者：徐涛[1] 刘保平[1] 孟玉葆[1] 孙秉奇[1] 牛广君[1] 韩星敏[1] 阮翘[1] 

机构地区：[1]郑州大学第一附属医院核医学科,450052

出　　处：《中华核医学杂志》2005年第1期14-16,i002,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的　探讨乏氧显像剂99Tcm 4 ,9 二氮 3,3,1 0 ,1 0 四甲基十二烷 2 ,1 1 二酮肟 (HL91 )检测心肌活性的可能性。方法　急性心肌梗死患者 2 5例 (病史≤ 6周 )和陈旧性心肌梗死患者 5例 (病史 >6周 )分别行硝酸甘油介入和静息99Tcm 甲氧基异丁基异腈 (MIBI)显像、99Tcm HL91显像 ,根据99Tcm MIBI显像结果将心肌分为正常心肌组、缺血心肌组 (硝酸甘油介入后99Tcm MIBI聚集量上升 >2 0 %)和梗死心肌组 (硝酸甘油介入后99Tcm MIBI聚集量上升≤ 2 0 %) ,比较三组间99Tcm HL91聚集量有无差别。结果①急性心肌梗死患者正常心肌组99Tcm HL91聚集量为 95 %,缺血心肌组为 1. 5 7%,梗死心肌组为93%,99Tcm HL91在缺血心肌组聚集量明显高于正常心肌组和梗死心肌组。②陈旧性心肌梗死患者三组间99Tcm HL91聚集量无差别。结论　99Tcm HL91可用于探测缺血但存活的心肌。Objective To investigate whether 99 Tc m 4,9 diaza 3,3,10,10 tetramethyldodecan 2,11 dione dioxime (HL91) can be used to distinguish ischemic myocardium segments from infarction segments. Methods Twenty five acute myocardial infarction patients (≤6 weeks) and 5 old myocardial infarction patients (>6 weeks) were included in the study. All the study patients underwent 99 Tc m HL91 and 99 Tc m methoxyisobutylisonitrile (MIBI) imaging intervented and unintervented with nitroglycerin, and the myocardium segments were divided into three groups according to 99 Tc m MIBI imaging results: normal, ischemic, and infarction myocardium segments. The difference of the radial counts of 99 Tc m HL91 in three groups were analyzed after the imaging with 99 Tc m HL91. Results ①In acute myocardial infarction patients, the accumulation rates of 99 Tc m HL91 was 95%in normal segment group, 157%in ischemic group, 93%in infarction group. The accumulation rates of 99 Tc m HL91 in the ischemic group was higher than that in the normal group and infarction group. ②In old myocardial infarction patients, the accumulation rates of 99 Tc m HL91 were of no difference among the normal, ischemic, and infarction groups. Conclusion 99 Tc m HL91 is a potential marker for detecting the ischemic myocardial tissue.

关 键 词：^99TC^M-HL91 缺血心肌 陈旧性心肌梗死 心肌活性 正常 患者 硝酸甘油 甲基 二酮 十二烷 

分 类 号：R817[医药卫生—影像医学与核医学]