糖皮质激素治疗儿童原发性鼻出血可行性探讨  

Possibility probe on glucocorticoid treating primary child epistaxis

作　　者：许心茂[1] 马亚琳[1] 张新东[2] 柴茂文[1] 

机构地区：[1]滕州市中心人民医院耳鼻咽喉科,山东滕州277500 [2]滕州市中心人民医院病理科

出　　处：《临床耳鼻咽喉科杂志》2005年第5期209-211,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的:探讨糖皮质激素治疗儿童原发性鼻出血(PCE)的可行性。方法:①通过二异氰酸甲苯酯滴鼻及搔刮鼻中隔前中部黏膜,建立家兔变应性鼻黏膜糜烂模型,将模型分为地塞米松组和抗生素组进行治疗。②问卷调查1000例学龄儿童鼻出血与鼻变态反应情况。③对200例PCE患儿分别用地塞米松加红霉素(治疗组)及单纯红霉素(对照组)进行治疗。结果:①地塞米松组家兔变应性鼻黏膜糜烂模型中隔创面愈合时间较抗生素组明显缩短。②变应性鼻炎患儿鼻出血发生率明显高于非变应性鼻炎者(P<0.01)。③临床治疗组疗效显著高于对照组(P<0.01)。结论:PCE与鼻变态反应关系极为密切,鼻局部变态反应足PCE的主要原因之一。糖皮质激素通过抑制鼻变态反应促进鼻中隔黏膜糜烂创面愈合,对PCE疗效显著。Objective:To probe the curative effect of glucocorticoid(GCD) on primary child epistaxis(PCE).Method:①Make rabbit model with nasal allergic reaction and nasal septum mucosa erosion,by dropping nose with toluene diisocyanate then curettaging front-middle-part of nasal septum mucosa.Divide them into two groups dexamethasone group and antibiotics group.②Questioning investigate the relationship between PCE and nasal allergic reaction to 1000 school children.③Two hundred cases of nasal bleeding children were divided into two growps dexamethasone-therapy-group and control-group.Result:①The healing period of rahbit nasal septum mucosa is much shorter in dexamethasone group than in another growp.②The genesis rate of school-children nasal bleeding is significantly higher in those with allergic rhinitis than in those without it.③The curative effect of therapy-group is much higher than that of control-group,there is significant difference.Conclusion:There is close relationship between PCE and nasal allergic reaction.Nasal allergic reaction is one of the most important reasons for child epista xis.Through inhibiting the allergic reaction,GCD can promote the erosive nasal septum mucosa healing.GCD has great curative effect on PCE.

关 键 词：糖皮质激素 鼻出血 儿童 

分 类 号：R765.23[医药卫生—耳鼻咽喉科]