急性脑死亡对移植供体心脏的影响  

The impact on the donor heart after acute brain death

作　　者：张明宇[1] 臧旺福[1] 吴乃石[1] 刘泉[1] 高宏[1] 孙露[1] 

机构地区：[1]哈尔滨医科大学附属第二医院心外科,150086

出　　处：《中华实验外科杂志》2005年第3期324-325,i009,共3页Chinese Journal of Experimental Surgery

基　　金：教育部2003年度优秀青年教师资助计划(2003159)

摘　　要：目的探讨急性脑死亡(BD)对机体造成的病理生理改变和对心脏造成的损伤及其机制。方法采用30～40kg体重的猪8只,制造BD前为对照组,BD后为实验组。测定BD前后血流动力学指标和血中生化学指标,并进行心肌活检。结果BD后心率增加了88%,收缩压升高了132%,心排量增加了80%、肾上腺素和去甲肾上腺素分别升高240%和241%,三碘甲腺原氨酸浓度显著下降,心肌形态学检查发现有心肌损害。结论BD可造成机体血流动力学的剧烈改变和心肌损害,血中儿茶酚胺含量升高和T3含量下降是造成心肌损伤的重要因素。Objective To investigate the pathophysiological changes of donor and donor heart after acute brain death and its mechanism.Methods Eight 30-40 kg pigs served as control group before acute brain death and as experimental group after acute brain death.Hemodynamic parameters and blood biochemical changes before and after brain death were measured.The cardiac morphological changes were observed after brain death.Results Heart rate was increased by 88%,blood pressure increased bt 132%,cardiac output increased by 80%,epinephrine and noradrenalin increased by 240% and 241% respectively after brain death.Triiodothyronine(T3) was significantly decreased.Myocardial damage was found.Conclusion Hyperdynamic response and myocardial damage appeared after acute brain death.It may be duo to the increase of catecholamine and the decrease of T3.

关 键 词：BD 急性 脑死亡 心脏 心肌损害 升高 血流动力学 三碘甲腺原氨酸 酸浓度 发现 

分 类 号：R654.2[医药卫生—外科学]