基质金属蛋白酶-9及其组织抑制物-1在人胎盘的表达及意义  

Expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in placenta.

作　　者：王轶英[1] 邹丽[1] 

机构地区：[1]华中科技大学附属协和医院妇产科,武汉430022

出　　处：《中国优生与遗传杂志》2005年第2期57-58,共2页Chinese Journal of Birth Health & Heredity

基　　金：湖北省妇幼项目基金资助

摘　　要：目的　研究基质金属蛋白酶 - 9(matrixmetalloproteinases ,MMP - 9)及其组织抑制物 - 1(tissueinhibitorofmetalloproteinases,TIMP - 1)在不同孕期胎盘中的表达及与滋养层细胞侵蚀、子宫 -胎儿血管系统建立的关系。方法　应用原位杂交法检测 5 6例胎盘 (早孕 16例、中孕 2 0例、晚孕 2 0例 )中MMP - 9及TIMP - 1mRNA的表达。结果　MMP - 9及TIMP - 1mRNA主要表达于滋养细胞、绒毛间质血管壁及蜕膜组织中 ;MMP - 9mRNA的表达早、中孕组明显强于晚孕组 ,TIMP - 1mRNA的表达晚孕组明显强于早、中孕组 ,差异均有极显著性 (P <0 .0 1)。结论　MMP - 9及TIMP - 1协同表达可能在滋养层细胞侵蚀、孕卵着床、血管重建过程中发挥一定的作用。Objective: To investigate the relationship between the messager RNA expression of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-1(TIMP-1) in placenta and trophoblast invasion, establishment of uterus-fetal vascular system. Methods: In placentas from 16 cases of the first trimester,20 cases from the second trimester and term pregnancy respectively, the expression of MMP-9/TIMP-1 mRNA were examined by in situ hybridization. Results: MMP-9 and TIMP-1 mRNA were expressed in trophoblast or vassal wall of villous stroma or decidual tissue. In the first and second trimester, the expression of MMP-9mRNA was significantly higher than that in term pregnancy(P<0.01) and the expression of TIMP-1 mRNA was significantly lower that in term pregnancy(P<0.01). Conclusion: MMP-9/TIMP-1 may play roles in trophoblast invasion, embryo implantation and vascular remodeling.

关 键 词：表达 TIMP-1 MMP-9 中孕 组织抑制物 晚孕 基质金属蛋白酶-9 人胎盘 RNA 滋养层细胞 

分 类 号：R714.5[医药卫生—妇产科学]