孕期Ⅱ型HSV感染对胎婴儿生长发育的影响  

The influence of typeⅡHSV infection during pregnancy on the development of fetus/neonates.

作　　者：邓东锐[1] 闻良珍[1] 凌霞珍[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《中国优生与遗传杂志》2005年第2期70-71,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的　探讨孕妇Ⅱ型单纯疱疹病毒 (HSV)感染及其对胎婴儿生长发育的影响。方法　应用酶联免疫吸附试验 (ELISA)和多聚酶链反应 (PCR)研究 4 5 5例孕妇及其胎婴儿Ⅱ型HSV感染状况及垂直传播途径。结果　异常组孕妇Ⅱ型HSV感染率 (6 1.0 1% )明显高于对照组 (2 7.0 4 % ) ;孕妇生殖道Ⅱ型HSV无症状排毒率为 3.0 7% ;羊水、胎盘及胎儿组织中均可检出Ⅱ型HSVDNA ;母婴间Ⅱ型HSV垂直传播率为 4 .2 4 %。结论　孕妇Ⅱ型HSV感染与异常妊娠关系密切。Ⅱ型HSV可经羊水、胎盘或产道感染胎婴儿。Objective: To explore the influence of type Ⅱ herpes simplex virus (HSV) infection during pregnancy on the development of fetus/neonates. Methods: Enzyme-linked immunosorbent assay (ELISA) combined with polymerase chain reaction (PCR) technique were used to study the state of type ⅡHSV infection in 455 pregnant women and their fetus/neonates, and the maternal-fetal transmission route. Results: The infective rate of type Ⅱ HSV in the blood of pregnant women with history of abnormal pregnancy (61.01%)was significantly higher than that of the control group(27.04%). The asymptomatic genital shedding rate of type Ⅱ HSV was 3.07%.TypeⅡ HSV DNA was detected in the amniotic fluid and tissues of placenta and fetus. The vertical transmission rate was 4.24%. Conclusion: The results suggest that typeⅡ HSV is closely related to the abnormal pregnancy. The fetus/neonates can be infected by TypeⅡ HSV via amniotic fluid 、placenta or genital tract.

关 键 词：Ⅱ型HSV 感染 孕妇 胎婴儿 垂直传播 

分 类 号：R714.2[医药卫生—妇产科学]