头孢地秦钠粉针剂治疗呼吸系统和泌尿系统感染的临床研究  

Treatment of Respiratory and Urinary Tract Infection with Cefodizime: A Randomized Controlled Multi center Clinical Study

作　　者：季淑娟[1] 吕芳芳[1] 俞云松[1] 陈亚岗[1] 郑经川[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《中华医院感染学杂志》2005年第2期127-130,共4页Chinese Journal of Nosocomiology

摘　　要：目的评价头孢地秦钠粉针剂(康丽能)治疗呼吸系统和泌尿系统感染的临床有效性与安全性. 方法采用多中心随机双盲平行对照的试验方法, 试验药组和对照药组各72例,总病例数为144例(呼吸系统感染96例和泌尿系统感染48例),进入PP分析的例数为 129例(呼吸系统感染84例,泌尿系统感染45例);治疗方案为每次2g静脉滴注,2次/d,疗程均为5～14 d. 结果头孢地秦钠治疗呼吸系统感染患者的痊愈率为79.07%、有效率为86.05%,细菌阴转率和细菌消除率为100.00%;治疗泌尿系统感染患者痊愈率为81.82%、有效率为95.45%,细菌阴转率为88.89%、消除率为100.00%;不良反应发生率为5.56%. 结论头孢地秦钠粉针剂对敏感菌所致的呼吸道和泌尿道感染,临床疗效肯定,不良反应轻,值得在敏感细菌感染的治疗中推广应用.OBJECTIVE To evaluate the efficacy and safety of cefodizime for respiratory and urinary tract infection. METHODS A total of 144 patients (96 with respiratory and 48 with urinary tract infection) entered a multi center randomized comparative trial. One hundred and twenty nine cases were analyzed by per protocal population analysis. Patients were divided into two groups treated with cefodizime (Kanglineng) as the treated group and cefodizime (Gaode) as the control group. The dosage was 2g bid for 5 14 days. RESULTS The effective rate, the cure rate, the bacterial negative rate and the bacterial eradication rate of Kanglineng were 86 05%, 79 07%, 100 00% and 100 00% for respiratory tract infection, while those were 95 45%, 81 82%, 88 89% and 100 00% for urinary tract infection. The incidence of adverse reaction was 5 56%. CONCLUSIONS Cefodizime (Kanglineng) is an effective and safe agent for treating respiratory and urinary tract infection.

关 键 词：头孢地秦钠 细菌清除率 有效率 

分 类 号：R969.3[医药卫生—药理学]