铜绿假单胞菌感染分布及药敏分析  

Distribution of Pseudomonas aeruginosa Infection and Drug Susceptibility Analysis

作　　者：徐黔宁[1] 王伟平[1] 张仙森[1] 

机构地区：[1]台州市第一人民医院,浙江台州318020

出　　处：《中华医院感染学杂志》2005年第2期213-214,共2页Chinese Journal of Nosocomiology

摘　　要：目的　了解本地区铜绿假单胞菌感染分布情况及对12种抗生素耐药性分析。方法　将分离培养的细菌经VITEK 32全自动微生物鉴定仪确诊的 95 株铜绿假单胞菌,记录其感染部位,标本来源,采用 GNS QB卡的 12种药物进行耐药性统计分析。结果　95株铜绿假单胞菌中有67株(70 5%)来自于上呼吸道(痰液及咽拭),其次是伤口分泌物21株(22 1%);药敏结果显示铜绿假单胞菌对β 内酰胺类抗生素有较高的耐药性,而对氨基糖苷类(阿米卡星、庆大霉素),喹诺酮类(环丙沙星),碳青酶烯类(亚胺培南/西司他丁)具有较高的敏感率。结论　铜绿假单胞菌感染以上呼吸道为主,可引起多部位感染,其对多种抗生素具有较高耐药性,应引起临床与实验室人员的重视,选择敏感药物或采取联合用药在治疗过程中具有重要意义。OBJECTIVE To understand the distribution of Pseudomoras aeruginosa infection in local district and make an analysis for its resistance to 12 antibiotics. METHODS To make definite diagnosis to 95 isolates through VITEK 32 automatic mircrobial monitor, mark the location of the infection and its root, cause and symptoms, and make a statistic analysis for resistance to 12 antibiotics by using GNS QB. RESULTS Sixty seven(70.5%) among 95 isolates come from upper respiratory tract(sputum, throat mucus), and another 21(22.1%) come from wound secretion. The result of drug susceptibility showed, that P. aeruginosa was a highly resistant to the β lactamase antibiotics, and had a higher susceptibility to aminoglycosides (amikacin, gentamicin), fluoroquinolones (ciprofloxacin) and carbapenems (imipenem). CONCLUSIONS P. aeruginosa mainly from upper respiratory tract, and it can cause infections in many other sites, but it is highly resistant to multi antibiotics. Close attention should be taken by the clinical and laboratory staff. It is of significance to select susceptible drugs or adopt combined treatment in the course of therapy.

关 键 词：铜绿假单胞菌 敏感率 耐药率 

分 类 号：R378.991[医药卫生—病原生物学]