铜绿假单胞菌耐碳青酶烯类抗菌药物机制分类检测的研究  

Classification Detection of Resistance Mechanisms in Pseudomonas aeruginosa to Carbapenem

作　　者：明德松[1] 吴一波[1] 朱焱[1] 谢尊金[1] 

机构地区：[1]泉州市第一医院,福建泉州362000

出　　处：《中华医院感染学杂志》2005年第2期215-216,共2页Chinese Journal of Nosocomiology

摘　　要：目的　研究铜绿假单胞菌(PA)耐碳青酶烯类抗菌药物机制的分布。方法　应用多底物 多抑制剂协同法检测34株耐碳青酶烯类抗菌药物PA临床分离株,推测其耐药机制并分析其分布。结果　D2 缺乏、外排泵和产金属酶分别占3种机制的14 7%、35 3%和50 0%。结论　产金属酶是PA耐碳青酶烯类抗菌药物最主要机制。OBJECTIVE To study the distribution of resistance mechanisms in Pseudomonas aeruginosa(PA) to carbapenem. METHODS To detect the 35 strains of PA isolates resistant to carbapenem by using a multi disk multi inhibitor synergy test (MDMIST), predicating the resistance mechanisms based on the phenotypes from MDMIST and analyzing the distribution of resistance mechanisms. RESULTS The percentage of produced metallo β lactamase, active efflux system and outer membrane porin D 2 in PA resistance to carbapenem is 14 7%, 35 3% and 50 0%, respectively. CONCLUSIONS Metallo β lactamase production is the main mechanism in PA resistance to carbapenem.

关 键 词：铜绿假单胞菌 碳青酶烯酶 金属酶 外排泵 

分 类 号：R378.991[医药卫生—病原生物学]