实验高压电烧伤软脑膜微循环动态变化和意义  

Dynamic Alteration and Significance on Pia Mater Microcirculation After High-voltage Electric Burn

作　　者：柯家祥[1] 张庆富[1] 王青[1] 王佳哲[1] 张景[1] 张海华[1] 

机构地区：[1]河北医科大学第一医院烧伤整形外科,河北石家庄050031

出　　处：《中国微循环》2005年第1期5-9,i001-i002,共7页Journal of Chinese Microcirculation

基　　金：河北省自然科学基金项目(编号 :302551)

摘　　要：目的通过研究高压电烧伤后动物软脑膜微循环的变化 ,探讨高压电对机体脑微循环的影响 ,为临床防治高压电脑损伤提供实验依据。方法复制家兔高压电烧伤模型 ,用WX -9B型微循环显微镜及视频图像分析系统 ,观察软脑膜微血管形态、微血管流态及微血管周围状态的变化 ,应用SAS软件进行统计学处理。结果与对照组比较,电烧伤(A、B)组软脑膜微血管形态、微血管流态及微血管周围状态各时相均发生变化 ,观察各时相高压电对微动脉和微静脉、毛细血管管径均有影响 (P<0.01),对微静脉血流速度亦有影响(P<0.01)。脑血流灌流值与对照组比较差别显著(P<0.01)。结论高压电烧伤能引起家兔软脑膜微循环发生病理性改变。Objective To observe the changes on pial microcirculation of rabbits after high_voltage electric burn(HEB),to study the effect on microcirculation and hydrodynamics by high_voltage electric injury and explore its mechanism,which may offer theoretical foundation for the prevention and cure of organ injury after high-voltage electric burn.Methods High_voltage electric burn model is duplicated.Exposed pia mater microcirculation is obˉserved with WX_9B Poly_position microcirculation instrument.Results Pial aterioles and venules all dilated after HEB from0～0.5hours,then contracted(P<0.01).Compared with normal group,boold perfusion of brain had evidently changed(P<0.01).Conclusions After HEB,cerebral microcirculation changes a lot.HEB can induce changes of rabbit's pia mater microcirculation.

关 键 词：高压电 烧伤 软脑膜 微循环 家兔 

分 类 号：R647[医药卫生—外科学] R331.35[医药卫生—临床医学]