四川省艾滋病病毒耐药性及影响因素  

Analysis for Investigation of HIV Drug Resistance and Influencing Factors in Sichuan Province

作　　者：刘莉[1] 郑国英[2] 吴晓敏 龚毅[2] 梁姝[2] 肖伟 戴卫东 

机构地区：[1]四川大学华西医学中心公共卫生学院,成都610041 [2]四川省疾病预防控制中心 [3]四川省资中县卫生局 [4]四川省乐山市中区疾病预防控制中心

出　　处：《预防医学情报杂志》2005年第1期1-5,共5页Journal of Preventive Medicine Information

摘　　要：目的　了解四川省艾滋病病毒耐药性及其影响因素 ,为制定合理的用药方案和减少耐药毒株的出现提供依据。方法　对接受过治疗和有待治疗的艾滋病感染者或患者进行面对面问卷调查并采血检测其耐药性。结果　共调查 5 3例艾滋病感染者或患者 ,2 8例有PCR扩增结果 ,1例正接受治疗 ,对地拉韦啶 (dilavirdine ,DLV)中度耐药 ,对依法韦伦 (efavirenz ,EFV)、奈韦拉平 (nevirapine ,NVP)高度耐药 ;1例未接受过治疗 ,对DLV、EFV、NVP高度耐药 ;总耐药率、治疗人群的耐药率、未治疗人群的耐药率分别为 7 14 %、 16 6 7%和 4 5 4% ;未产生耐药的治疗患者依从性较好 ,耐药患者药物漏服现象明显。结论　四川省开展和未开展艾滋病抗病毒治疗的感染者或患者均存在不同程度的耐药 ,应采用可行的督导服药方式以提高患者依从性 ,同时将耐药性检测作为经常性工作 ,以指导四川省的艾滋病抗病毒药物治疗。Objective To understand HIV drug resistance and its influencing factors in Sichuan Province for producing reasonable ARV prescriptions and reducing drug resistance. Method Face to face investigation and blood collection for drug resistance detection were conducted among treated and non-treated HIV/AIDS cases. Result A total of 53 HIV/AIDS cases were investigated and 28 cases had PCR results. One treated case of them was mildly resistant to dilavirdine (DLV) and highly to efavirenz (EFV) and nevirapine (NVP), and one non-treated case was highly resistant to DLV, EFV, and NVP. The rate of drug resistance among investigated, treated, and non-treated people was 7.14%, 16.67%, and 4.54% respectively. Treated cases sensitive to ARV had good compliance to taking medicine, while resistant cases forgot to take medicine many times. Conclusion Drug resistance exists differently among treated and non-treated HIV/AIDS cases. Compliance to taking drug should be increased by a feasible way, and drug resistance detection should be conducted often to guide ARV therapy in our province.

关 键 词：人类免疫缺陷病毒 耐药性 影响因素 

分 类 号：R512.91[医药卫生—内科学]